171820-17-0

Basic information

• Product Name: 2,5-bis-(4-methoxyphenyl)-pyridine
• Synonyms: 2,5-bis-(4-methoxyphenyl)-pyridine
• CAS NO: 171820-17-0
• Molecular Formula: C₁₉H₁₇NO₂
• Molecular Weight: 291.34378
• Mol File: 171820-17-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,5-bis-(4-methoxyphenyl)-pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-bis-(4-methoxyphenyl)-pyridine(171820-17-0)
• EPA Substance Registry System: 2,5-bis-(4-methoxyphenyl)-pyridine(171820-17-0)

Safety Data

• Hazardous Substances Data: 171820-17-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
2,5-bis-(4-methoxyphenyl)-pyridine is used as a target for drug development due to its demonstrated antioxidant, anti-inflammatory, and anti-cancer properties. Its potential to modulate various biological pathways makes it a promising candidate for the creation of new therapeutic agents.
Used in Organic Synthesis:
In the field of organic synthesis, 2,5-bis-(4-methoxyphenyl)-pyridine serves as a useful building block for the synthesis of more complex organic molecules. Its unique reactivity allows for the creation of a variety of chemical structures, which can be further utilized in different applications.
Used in Chemical Research:
2,5-bis-(4-methoxyphenyl)-pyridine is employed as a subject of study in chemical research to explore its properties and potential applications. Its versatility and the possibility of modifying its structure to achieve desired outcomes make it an important compound for advancing scientific knowledge in chemistry.
Used in Industrial Processes:
2,5-bis-(4-methoxyphenyl)-pyridine is also utilized in various industrial processes where its chemical properties are harnessed for specific applications. Its wide range of uses in the industry highlights its importance in the development and manufacturing of various products.

Upstream product

• 624-28-2 2,5-dibromopyridine 
• 5720-07-0 4-methoxyphenylboronic acid 
• 171364-79-7 2-(4-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 116195-81-4 2,5-di-iodopyridine 
• 121-46-0 bicyclo[2.2.1]hepta-2,5-diene 
• 64327-01-1 3,6-bis(4-methoxyphenyl)-1,2,4-triazine 
• 3290-99-1 4-methoxybenzoic acid hydrazide 
• 2632-13-5 2-Bromo-4'-methoxyacetophenone 

Downstream Products

• 155266-51-6 2,5-bis(4-hydroxy-phenyl) pyridine 
• 871096-48-9 2,5-bis-[4-(2-benzyloxy-ethoxy)-phenyl]pyridine 

Relevant articles and documents

Coumarin-pyridine push-pull fluorophores: Synthesis and photophysical studies

A series of coumarin-pyridine-based push-pull fluorophores were prepared starting from 1,2,4-triazines by using direct C-H functionalization (SNH-reaction)–Diels-Alder–retro Diels-Alder domino reaction sequence. This efficient synthetic strategy allowed to obtain a series of 19 coumarin-pyridine fluorophores. Their photophysical properties were studied. While pyridine-substituted derivatives of 4-alkylcoumarins may be considered as alternative to coumarin dyes characterized by emission maxima mainly in a visible region with wavelengths of 402–415 nm, absorption in the UV range at 210–307 nm, and good photoluminescence quantum yields of 6–19%, all the derivatives of 4-phenylcoumarin did not exhibit any noticeable fluorescence. More detailed photophysical studies were carried out for two the most representative derivatives of 4-alkyl-coumarin-pyridines to demonstrate their positive solvatochromism, and the collected data were analyzed by using Lippert-Mataga equation, as well as Kosower and Dimroth/Reichardt scales. The obtained results demonstrate that the combining two chromophore systems, such as 2,5-diarylpyridine and coumarin ones, is promising in terms of improving the photophysical properties of the new coumarin-pyridine hybrid compounds.

Efficient Suzuki-Miyaura mono-arylation of symmetrical diiodo(hetero)arenes

A reliable protocol for converting 1,4-diiodo-2,3,5,6-tetrafluorobenzene into 1-(hetero)aryl-4-iodo-2,3,5,6-tetrafluorobenzene derivatives has been lacking in the literature. We have identified optimal conditions to achieve this conversion in good yields and have minimized formation of the bis-coupling product. The newly identified protocol involving the use of a syringe pump has been extended to other symmetrical diiodo(hetero)arenes.

Preparation method of phenyl triazine compound and preparation method of phenyl pyridine compound

The invention relates to the technical field of compound synthesis, in particular to a preparation method of phenyl triazine compound and preparation method of the phenyl pyridine compound, the preparation method of phenyl triazine compound and preparation method of phenyl pyridine compound takes the compound having the structure represented by the formula (I), the compound having the structure represented by the formula (II), organic protic acid, the ammonium salt and the first organic solvent to undergo nucleophilic addition reaction and ring reaction to prepare the phenyl triazine compoundwith the structure shown by the formula (III), no noble metal catalyst is needed in the reaction, the reaction yield and the purity are higher, and then carries out inverse Diels-Alder reaction with the phenyl triazine compound prepared by the above method with the structure shown in the formula (III), the norbornene diene and the second organic solvent to obtain the phenyl pyridine compound withthe structure represented by the formula (VI), wherein no noble metal catalyst is needed in the reaction, the reaction yield and purity are both high. Besides, the preparation method provided is concise in route, good in process controllability, low in cost and easy for industrial production.

Aryl 5-substitution of a phenyl-pyridine based ligand as a viable way to influence the opto-electronic properties of bis-cyclometalated Ir(iii) heteroleptic complexes

This manuscript reports on the synthesis, the photophysical study and the electroluminescent properties of a series of heteroleptic cyclometalated iridium(iii) complexes based on 2,5-diaryl-pyridines as C^N cyclometalating ligands and acetylacetonate as ancillary ligand. The complexes were characterised by elemental analysis, ESI-MS, multinuclear NMR, TGA and electrochemistry. Their optical properties were investigated by UV-Vis and photoluminescence. DFT and TD-DFT calculations provided further insights into the effects of the 5-aryl substitution on the electronic and photophysical properties of the new complexes. The presence of suitable π-extended ligands exerts a beneficial effect on the performances of the corresponding solution-processed light-emitting diodes, leading to a maximum brightness of 10620 cd m-2 at a current efficiency of 10.0 cd A-1.

Synthesis of 2,5- and 3,5-diphenylpyridine derivatives for DNA recognition and cytotoxicity

A series of 2,5- and 3,5-diphenylpyridine derivatives was synthetised in high yields. A versatile chemical strategy allows the design of diphenylpyridines differently substituted with cationic or neutral side chains. The interaction of the molecules with