- Synthesis and Photophysical Studies on Naphthalimide Derived Fluorophores as Markers in Drug Delivery
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Derivatives of 4-amino-1,8-naphthalimide containing a free alkyl chain bearing carboxyl group as linker and different substituents at 4-amino function have been synthesized, characterized and studied for their photophysical properties. Steady state fluorescence studies showed quantum yield varied from 0.45 to 0.65 with Stokes shift in the range of 5824–8558?cm?1. Spectroscopic and physicochemical parameters, like electronic absorption, emission, and extinction coefficient were investigated in order to explore the analytical potential of compounds. Solvatochromic studies demonstrated that all compounds were sensitive towards the polarity of different solvents showing the highest degree of fluorescence in acetonitrile. In addition, the compounds in the presence of ions, viz. Na+, K+ and Mg2+ at concentration of 0.1–2 equivalents, showed a decreasing trend in fluorescence with increasing ionic concentration. TCSPC set – up was used to measure the fluorescence lifetime of compounds, which was found to be bi-exponential with longer and shorter component at their respective amplitudes. The average lifetime of compounds was observed to be 5.76–9.96?ns indicating the possibility of their greater utilization in research and diagnosis.
- Singh, Nidhi,Srivastava, Ritika,Singh, Anuradha,Singh, Ramendra K.
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- Versatile fluorescence labeling method using activated esters on solid support
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A versatile fluorescence labeling method employing support bound nitrophenyl, N-hydroxysuccinimidyl, 1-hydroxybenzotriazoyl and oxime active esters is described. The relative kinetic properties of different esters were systematically compared using an env
- Chang, Young-Tae,Schultz, Peter G.
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- A novel bifunctional fluorescent tag for use in molecular biology
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Synthesis and characterization of a new, highly fluorescent label, 4-acetylamino-1,8-naphthalimide-N-caproic acid (6) have been described.The synthesis of this molecule has been effected starting from acenaphthene, a non-fluorescent starting compound, through a series of chemical reactions.
- Dubey, Krishna K.,Singh, Ramendra K.,Misra, Krishna
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p. 876 - 878
(2007/10/03)
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