17228-70-5

Basic information

• Product Name: 3,5-Dichloro-4-hydroxypyridine
• Synonyms: LABOTEST-BB LT00455416;IFLAB-BB F1957-0005;AKOS 90467;3,5-DICHLORO-4-PYRIDINOL;3,5-dichloro-4-pyridinone;3,5-DICHLORO-4-PYRIDONE;3,5-DICHLORO-4-HYDROXYPYRIDINE;3,5-DICHLORO-4(1H)-PYRIDINONE
• CAS NO: 17228-70-5
• Molecular Formula: C₅H₃Cl₂NO
• Molecular Weight: 163.99
• EINECS: 215-885-0
• Product Categories: Pyridine;Pyridines;Chloropyridines;Halopyridines
• Mol File: 17228-70-5.mol

Chemical Properties

• Melting Point: 56-59 °C(lit.)
• Boiling Point: 242.6 °C at 760 mmHg
• Flash Point: 100.5 °C
• Appearance: white to off-white solid
• Density: 1.52 g/cm³
• Vapor Pressure: 0.0616mmHg at 25°C
• Refractive Index: 1.605
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: DMSO (Slightly)
• PKA: 7.31±0.69(Predicted)
• Stability: Hygroscopic
• BRN: 1524978
• CAS DataBase Reference: 3,5-Dichloro-4-hydroxypyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-Dichloro-4-hydroxypyridine(17228-70-5)
• EPA Substance Registry System: 3,5-Dichloro-4-hydroxypyridine(17228-70-5)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 22-36/37/38
• Safety Statements: 36/37/39-26-22-36
• WGK Germany: 3
• HazardClass: IRRITANT
• PackingGroup: III
• Hazardous Substances Data: 17228-70-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
3,5-Dichloro-4-hydroxypyridine is used as a key intermediate in the synthesis of pharmaceuticals for its ability to be incorporated into various drug molecules, enhancing their therapeutic properties and effectiveness.
Used in Agrochemical Production:
In the agrochemical industry, 3,5-Dichloro-4-hydroxypyridine is utilized as a precursor in the development of pesticides and other agrochemicals, contributing to the creation of more effective and targeted products for agricultural use.
Used in Organic Chemistry:
3,5-Dichloro-4-hydroxypyridine serves as a versatile building block in organic chemistry, used in the synthesis of a wide range of organic compounds for various applications, including the development of new materials and chemical products.
Used in the Development of Biologically Active Compounds:
Due to its unique structure and reactivity, 3,5-Dichloro-4-hydroxypyridine is employed as a component in the research and development of biologically active compounds, potentially leading to advancements in medicine and other fields.

InChI:InChI=1/C5H3Cl2NO/c6-3-1-8-2-4(7)5(3)9/h1-3H

Upstream product

• 108-96-3 4-pyridone 

Downstream Products

• 56187-37-2 2-(3,5-dichloro-4-oxopyridine-1(4H)-yl)acetic acid 

Relevant articles and documents

The Preparation and Characterization of Some N-Chloro-2- and N-Chloro-4-pyridones

2-Pyridone and 5-chloro-2-pyridone with NaOCl yield 1-chloro-2-pyridone and 1,5-dichloro-2-pyridone, respectively, which rapidly rearrange into 5-chloro- and 3,5-dichloro-2-pyridone. 3,5-Dichloro-2-pyridone with NaOCl yields 1,3,5-trichloro-2-pyridone which shows considerable stability. 4-Pyridone is similarly converted by NaOCl into 3,5-dichloro-4-pyridone via an unstable N-chloro derivative. 1,3,5-Trichloro-4-pyridone was obtained from 3,5-dichloro-4-pyridone and NaOCl.