172324-65-1

Basic information

• Product Name: TRANS-3-BENZYLOXYMETHYLCYCLOBUTANOL
• Synonyms: TRANS-3-BENZYLOXYMETHYLCYCLOBUTANOL;3-(benzyloxyMethyl)cyclobutanol;trans-3-[(Phenylmethoxy)methyl]cyclobutanol;(1R,3R)-3-((Benzyloxy)Methyl)cyclobutanol
• CAS NO: 172324-65-1
• Molecular Formula: C₁₂H₁₆O₂
• Molecular Weight: 192.25
• Mol File: 172324-65-1.mol

Chemical Properties

• Boiling Point: 297℃
• Flash Point: 124℃
• Appearance: /
• Density: 1.113
• Refractive Index: 1.557
• Storage Temp.: 2-8°C
• PKA: 15.10±0.40(Predicted)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: TRANS-3-BENZYLOXYMETHYLCYCLOBUTANOL(CAS DataBase Reference)
• NIST Chemistry Reference: TRANS-3-BENZYLOXYMETHYLCYCLOBUTANOL(172324-65-1)
• EPA Substance Registry System: TRANS-3-BENZYLOXYMETHYLCYCLOBUTANOL(172324-65-1)

Safety Data

• Hazardous Substances Data: 172324-65-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
TRANS-3-BENZYLOXYMETHYLCYCLOBUTANOL is used as a raw material intermediate for the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of new drugs with potential therapeutic applications, such as those targeting specific diseases or conditions.
Used in Chemical Industry:
In the chemical industry, TRANS-3-BENZYLOXYMETHYLCYCLOBUTANOL is utilized as an intermediate in the production of various chemical products. Its versatile structure enables the creation of a wide range of compounds with diverse applications, including those in materials science, coatings, and specialty chemicals.
By understanding the structure and properties of TRANS-3-BENZYLOXYMETHYLCYCLOBUTANOL, researchers and chemists can continue to explore its potential applications in various industries, leading to the development of innovative products and solutions.

InChI:InChI=1/C12H16O2/c13-12-6-11(7-12)9-14-8-10-4-2-1-3-5-10/h1-5,11-13H,6-9H2/t11-,12-

Upstream product

• 172324-67-3 3-benzyloxymethyl-cyclobutanone 
• 172324-70-8 (1r,3r)-3-((benzyloxy)methyl)cyclobutyl 4-nitrobenzoate 
• 172324-68-4 (1s,3s)-3-((benzyloxy)methyl)cyclobutanol 
• 14593-43-2 benzyl allyl ether 
• 172324-66-2 3-(benzyloxymethyl)-2,2-dichlorocyclobutanone 
• 100-51-6 benzyl alcohol 

Downstream Products

• 172324-63-9 9--6-(4-chlorophenylsulfanyl)-9H-purine 
• 172324-62-8 9--6-(4-chlorophenylsulfanyl)-2-(phenylacetamido)-9H-purine 
• 215544-48-2 2-(3-Benzyloxymethyl-cyclobutoxy)-4-benzylsulfanyl-pyrimidine 
• 215544-51-7 3-Benzoyl-1-(3-benzyloxymethyl-cyclobutyl)-1H-pyrimidine-2,4-dione 
• 890529-15-4 C₂₃H₂₁FN₂O₄ 
• 890529-16-5 C₁₆H₁₇FN₂O₃ 
• 215544-52-8 1-(3-Benzyloxymethyl-cyclobutyl)-1H-pyrimidine-2,4-dione 
• 215544-53-9 1-(3-Benzyloxymethyl-cyclobutyl)-5-methyl-1H-pyrimidine-2,4-dione 
• 125962-36-9 9-adenine 
• 125962-37-0 9-guanine 
• 172324-64-0 9-adenine 
• 172324-60-6 9--2-N-(phenylacetyl)guanine 
• 172324-61-7 9--2-N-(phenylacetyl)guanine 
• 908570-14-9 trans-3-[(benzyloxy)methyl]cyclobutyl-p-toluenesulphonate 

Relevant articles and documents

IRAK DEGRADERS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same. The compounds include an IRAK binding moiety capable of binding to IRAK4 and a degradation inducing moiety (DIM). The DIM could be DTM a ligase binding moiety (LBM) or lysine mimetic. The compounds could be useful as IRAK protein kinase inhibitors and applied to IRAK mediated disorders.

Synthesis and evaluation of 2′-substituted cyclobutyl nucleosides and nucleotides as potential anti-HIV agents

A series of 2′-substituted cyclobutyl nucleoside analogs were efficiently prepared by constructing the core cyclobutyl ring using different [2+2] cycloaddition approaches. The triphosphate derivative of a cyclobutyl nucleoside was also synthesized and eva

USE OF PDE7 INHIBITORS FOR THE TREATMENT OF NEUROPATHIC PAIN

The present invention relates to the use of a phosphodiesterase 7 (PDE7) inhibitor in the manufacture of a medicament for the treatment of neuropathic pain and to a method of treating neuropathic pain using an inhibitor of PDE7.

Synthesis of 9--adenine and -guanine

2,2-Dichloro-3-(benzyloxymethyl)cyclobutanone 15, which was prepared in 50percent yield by the cycloaddition of dichloroketene to allyl benzyl ether 14, was converted in four steps and in ca. 40percent overall yield into trans-3-(benzyloxymethyl)cyclobutanol 11b.The latter alcohol 11b was coupled under Mitsunobu conditions with 6-(4-chlorophenylsulfanyl)-9H-purine 21b and 6-(4-chlorophenylsulfanyl)-2-(phenylacetamido)-9H-purine 21c to give the 9-cyclobutylpurine derivatives 22 and 24, respectively, in 88 and 60percent yield.The former product 22 was converted in three steps and in 39percent overall yield into 9-adenine 6, and the latter product was converted in four steps and in 42percent overall yield into 9-guanine 7.X-Ray crystallographic data relating to compounds 22 and 24 are also reported.