- SYNTHESIS OF ALKYL β-GLYCOSIDES OF 6-(N-ACETYLMURAMOYL-L-ALANYL-D-ISOGLUTAMINYLAMINO)HEXANOIC ACID AND ITS 4-AMINOBUTYL ESTER.
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The synthesis has been effected of alkyl β-glycosides containing spacers with amino and carboxy groups at the end.As "prespacers" we used benzyl and 4-azidobutyl esters of 6-(L-alanyl-D-isoglutaminylamino)hexanoic acid.The use of the butyl and hexadecyl β
- Kur'yanov, V.O.,Tsikalov, V.V.,Zemlyakov, A.E.,Chirva, V.Ya.
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Read Online
- A novel solid-phase reductive alkylation route to acridine and dansyl polyamine conjugates
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Solid-phase organic synthesis (SPOS) routes to target unsymmetrical polyamines and their acridinyl and dansyl conjugates have been developed based upon borane-pyridine complex (BAP) mediated reductive alkylation, azide reduction with triphenylphosphine, and the use of pent-4-enoyl (Pnt) as an orthogonal amine protecting group.
- Carrington, Simon,Renault, Jacques,Tomasi, Sophie,Corbel, Jean-Charles,Uriac, Philippe,Blagbrough, Ian S.
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Read Online
- Solid-phase supports and uses thereof
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The present disclosure relates to solid-phase azide supports, methods for making solid-state azide supports, and methods for capturing alkynes using the same. The present disclosure also relates to kits for solid-phase azide supports.
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Page/Page column 15
(2016/08/07)
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- Solid-Phase Supports and Uses Thereof
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The present disclosure relates to solid-phase azide supports, methods for making solid-state azide supports, and methods for capturing alkynes using the same. The present disclosure also relates to kits for solid-phase azide supports
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- Synthesis of acyclovir and HBG analogues having nicotinonitrile and its 2-methyloxy 1,2,3-triazole
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Reaction of pyridin-2(1H)-one 1 with 4-bromobutylacetate (2), (2-acetoxyethoxy)methyl bromide (3) gave the corresponding nicotinonitrile O-acyclonucleosides, 4 and 5, respectively. Deacetylation of 4 and 5 gave the corresponding deprotected acyclonucleosi
- Moustafa, Ahmed H.,El-Sayed, Hassan A.,Haikal, Abd El-Fattah Z.,El Ashry, El Sayed H.
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scheme or table
p. 340 - 352
(2011/10/18)
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- Selection of the biological activity of DNJ neoglycoconjugates through click length variation of the side chain
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A series of neoglycoconjugates derived from deoxynojirimycin has been prepared by click connection with functionalised adamantanes. They have been assayed as glycosidase inhibitors, as inhibitors of the glycoenzymes relevant to the treatment of Gaucher disease, as well as correctors of the defective ion-transport protein involved in cystic fibrosis. We have demonstrated that it is possible to selectively either strongly inhibit ER-α-glucosidases and ceramide glucosyltransferase or restore the activity of CFTR in CF-KM4 cells by varying the length of the alkyl chain linking DNJ and adamantane.
- Ardes-Guisot, Nicolas,Alonzi, Dominic S.,Reinkensmeier, Gabriele,Butters, Terry D.,Norez, Caroline,Becq, Frederic,Shimada, Yousuke,Nakagawa, Shinpei,Kato, Atsushi,Bleriot, Yves,Sollogoub, Matthieu,Vauzeilles, Boris
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supporting information; experimental part
p. 5373 - 5388
(2011/08/22)
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- Synthesis and biological evaluation of some 4-substituted 1-[1-(4-hydroxybutyl)-1,2,3-triazol-(4 & 5)-ylmethyl]-1H-pyrazolo [3,4-d]pyrimidines
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The synthesis of 1-[1-(4-hydroxybutyl)-1,2,3-triazol-(4 and 5)-ylmethyl]-1H-pyrazolo[3,4-d] pyrimidines 11a,b, 12a,b and 13-17 as carboacyclic nucleosides is described. The compounds 8a,b were condensed, separately, with compound 7 via 1,3-dipolar cycload
- Moukha-Chafiq,Taha,Lazrek,Vasseur,Pannecouque,Witvrouw,De Clercq
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p. 1811 - 1821
(2007/10/03)
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- An intramolecular [2 + 3] cycloaddition route to fused 5-heterosubstituted tetrazoles
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(matrix presented) Fused 5-heterotetrazole ring systems are synthesized in high yield via intramolecular [2 + 3] cycloadditions of organic azides and heteroatom-substituted nitriles. Cyanates, thiocyanates, and cyanamides are all competent dipolarophiles for this reaction. A variety of scaffolds are tolerated when the new enclosed ring is five- or six-membered.
- Demko, Zachary P.,Sharpless, K. Barry
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p. 4091 - 4094
(2007/10/03)
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- Synthesis of new 1,2,3-triazole acyclonucleoside analogues of ACV and HBG
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1,3-dipolar cycloaddition of N-9/N-1-propargylpurine/pyrimidine to the corresponding azidocompounds 9-10 produces acyclonucleoside analogues 13a-h, 14a-h in which the 4-methyl-1,2,3-triazole is used as spacer arm.
- Lazrek,Taourirte,Oulih,Lebtoumi,Barascut,Imbach
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p. 1115 - 1118
(2007/10/03)
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