- A phenylacetic acid compound preparation method (by machine translation)
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The invention relates to the field of chemical synthesis, in particular relates to a preparation method of the compound of phenylacetic acid. The present invention provides a preparation method of the compound of phenylacetic acid, the acid compounds of the structural formula states the benzene second grade shown in formula I, the preparation method comprises the following steps: (1) diazo addition reaction: formula II compound containing vinylidene chloride, acid, diazotization reagent, phase transfer catalyst and a copper catalyst in the system of the formula III compound: (2) hydrolysis reaction: the compound of formula III in the presence of acid hydrolysis of formula I compounds. The present invention provides a preparation method of and is simple, easy operation, low cost of raw materials, mild reaction conditions, low risk, does not need to use expensive noble metal catalyst and complex industrial operation means, the product quality is stable, therefore easy achievement of large-scale industrial production. (by machine translation)
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- Exalted resonance demands in the substituent effects on the acetolyses of 2-arylethyl trifluoromethanesulfonates destabilized by cn and cf3 groups
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Substituent effects on the acetolysis rates of 2-aryl-l-cyano-l- (trifluoromethyl)ethyl trifluoromethanesulfonates (α-OTf) and 2-aryl-2-cyano-2-(trifluoromethyl)ethyl trifluoromethanesulfonates (ss-OTf) were investigated by using LArSR equation. The obtained p and r+ values were p = -3.28, r+ = 0.98 and p = -3.48,r+ = 0.93 for the acetolysis of α-OTf and ss-OΥi, respectively. The obtained p values are comparable to those for typical aryl-assisted solvolyses, but the r+ values are much larger. The large r+ values suggest that the ester bond cleavages in the deactivated aryl-assisted solvolyses are assisted by the strong participation of the ss-aryl group.
- Usui, Satoshi,Tsuboya, Shoko,Umezawa, Yukthiro,Hazama, Ken,Okamura, Mutsuo
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experimental part
p. 254 - 260
(2009/05/30)
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- Quinolones as gonadotropin releasing hormone (GnRH) antagonists: Simultaneous optimization of the C(3)-aryl and C(6)-substituents
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A series of 3-arylquinolones was prepared and evaluated for their ability to act as gonadotropin releasing hormone (GnRH) antagonists. A variety of substitution patterns of the 3-aryl substituent are described. The 3,4,5-trimethylphenyl substituent (23h) was found to be optimal. (C) 2000 Elsevier Science Ltd. All rights reserved.
- Young, Jonathan R.,Huang, Song X.,Chen, Irene,Walsh, Thomas F.,DeVita, Robert J.,Wyvratt Jr., Matthew J.,Goulet, Mark T.,Ren, Ning,Lo, Jane,Yang, Yi Tien,Yudkovitz, Joel B.,Cheng, Kang,Smith, Roy G.
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p. 1723 - 1727
(2007/10/03)
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