17283-16-8

Basic information

• Product Name: 3,4-Dimethylphenylacetic Acid
• Synonyms: (3,4-dimethylphenyl)acetic acid(SALTDATA: FREE);3,4-Dimethyl-Benzeneacetic Acid;2-(3,4-Dimethylphenyl);Benzeneacetic acid, 3,4-dimethyl-
• CAS NO: 17283-16-8
• Molecular Formula: C₁₀H₁₂O₂
• Molecular Weight: 164.21
• EINECS: 245-129-5
• Mol File: 17283-16-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 297.3 °C at 760 mmHg
• Flash Point: 194.4 °C
• Appearance: /Solid
• Density: 1.098 g/cm³
• Vapor Pressure: 0.0508mmHg at 25°C
• Refractive Index: 1.503
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 3,4-Dimethylphenylacetic Acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-Dimethylphenylacetic Acid(17283-16-8)
• EPA Substance Registry System: 3,4-Dimethylphenylacetic Acid(17283-16-8)

Safety Data

• Hazardous Substances Data: 17283-16-8(Hazardous Substances Data)

Usage

Uses

3,4-Dimethylphenylacetic acid, is is used as an intermediate in organic synthesis. It is also used as a fine chemical intermediate.

InChI:InChI=1/C10H12O2/c1-7-4-5-10(6-8(7)2)12-9(3)11/h4-6H,1-3H3

Upstream product

• 95-64-7 4-amino-o-xylene 
• 90920-12-0 1-(2,2,2-trichloroethyl)-3,4-dimethylbenzene 
• 3637-01-2 3,4-dimethylacetophenone 
• 3020-06-2 3,4-dimethylphenylacetonitrile 
• 186581-53-3 diazomethane 
• 21900-23-2 3,4-dimethylbenzoyl chloride 
• 101114-04-9 4-[(3,4-dimethyl-phenyl)-thioacetyl]-morpholine 

Downstream Products

• 85175-47-9 N-(2,2-dimethoxyethyl)-3,4-dimethyl-phenylacetamide 
• 87776-80-5 2-(3,4-dimethylphenyl)-1-ethanol 
• 18215-12-8 N-[2-(3,4-Dimethoxy-phenyl)-ethyl]-2-(3,4-dimethyl-phenyl)-acetamide 
• 47291-28-1 1-(3,4-dimethyl-benzyl)-6,7-dimethoxy-3,4-dihydro-isoquinoline 
• 361389-51-7 1-(3,4-Dimethyl-benzyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline 
• 112282-31-2 1-(3,4-dimethylphenylacetyl)-2-(1-pyrrolidinylmethyl)-piperidine hydrochloride 

Relevant articles and documents

A phenylacetic acid compound preparation method (by machine translation)

The invention relates to the field of chemical synthesis, in particular relates to a preparation method of the compound of phenylacetic acid. The present invention provides a preparation method of the compound of phenylacetic acid, the acid compounds of the structural formula states the benzene second grade shown in formula I, the preparation method comprises the following steps: (1) diazo addition reaction: formula II compound containing vinylidene chloride, acid, diazotization reagent, phase transfer catalyst and a copper catalyst in the system of the formula III compound: (2) hydrolysis reaction: the compound of formula III in the presence of acid hydrolysis of formula I compounds. The present invention provides a preparation method of and is simple, easy operation, low cost of raw materials, mild reaction conditions, low risk, does not need to use expensive noble metal catalyst and complex industrial operation means, the product quality is stable, therefore easy achievement of large-scale industrial production. (by machine translation)

Quinolones as gonadotropin releasing hormone (GnRH) antagonists: Simultaneous optimization of the C(3)-aryl and C(6)-substituents

A series of 3-arylquinolones was prepared and evaluated for their ability to act as gonadotropin releasing hormone (GnRH) antagonists. A variety of substitution patterns of the 3-aryl substituent are described. The 3,4,5-trimethylphenyl substituent (23h) was found to be optimal. (C) 2000 Elsevier Science Ltd. All rights reserved.