17288-55-0

Basic information

• Product Name: 5-METHOXY-1H-PYRROLO[3,2-B]PYRIDINE-3-CARBALDEHYDE
• Synonyms: 5-METHOXY-1H-PYRROLO[3,2-B]PYRIDINE-3-CARBALDEHYDE;5-methoxy-1H-Pyrrolo[3,2-b]pyridine-3-carboxaldehyde
• CAS NO: 17288-55-0
• Molecular Formula: C9H8N2O2
• Molecular Weight: 176.17
• Mol File: 17288-55-0.mol

Chemical Properties

• Boiling Point: 363.3°C at 760 mmHg
• Flash Point: 173.5°C
• Appearance: /
• Density: 1.347g/cm³
• Vapor Pressure: 1.82E-05mmHg at 25°C
• Refractive Index: 1.691
• CAS DataBase Reference: 5-METHOXY-1H-PYRROLO[3,2-B]PYRIDINE-3-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-METHOXY-1H-PYRROLO[3,2-B]PYRIDINE-3-CARBALDEHYDE(17288-55-0)
• EPA Substance Registry System: 5-METHOXY-1H-PYRROLO[3,2-B]PYRIDINE-3-CARBALDEHYDE(17288-55-0)

Safety Data

• Hazardous Substances Data: 17288-55-0(Hazardous Substances Data)

Usage

Uses

Used in Medicinal Chemistry:
5-Methoxy-1H-pyrrolo[3,2-b]pyridine-3-carbaldehyde is used as a building block in the synthesis of various pharmaceuticals and organic molecules. Its unique structure and potential biological activities make it a valuable component in the development of new drugs and therapeutic agents.
Used in Drug Discovery:
In the field of drug discovery, 5-Methoxy-1H-pyrrolo[3,2-b]pyridine-3-carbaldehyde is utilized for its potential to contribute to the creation of novel compounds with therapeutic properties. Its specific properties and potential uses can be further studied and explored in research and development efforts, leading to the identification of new drug candidates and treatment options.
Used in Pharmaceutical Industry:
5-Methoxy-1H-pyrrolo[3,2-b]pyridine-3-carbaldehyde is used as a key intermediate in the synthesis of pharmaceutical compounds. Its unique structure allows for the development of new drugs with improved efficacy and selectivity, contributing to advancements in the treatment of various diseases and medical conditions.
Used in Organic Chemistry Research:
In the realm of organic chemistry research, 5-Methoxy-1H-pyrrolo[3,2-b]pyridine-3-carbaldehyde serves as a valuable compound for studying the synthesis and properties of complex organic molecules. Its unique structure and potential reactivity provide opportunities for exploring new reaction pathways and developing innovative synthetic methods.
Used in Chemical Synthesis:
5-Methoxy-1H-pyrrolo[3,2-b]pyridine-3-carbaldehyde is employed as a versatile building block in chemical synthesis, enabling the creation of a wide range of organic molecules with diverse applications. Its unique structure and functional groups facilitate the development of new synthetic routes and the production of novel compounds with potential uses in various industries.

InChI:InChI=1/C9H8N2O2/c1-13-8-3-2-7-9(11-8)6(5-12)4-10-7/h2-5,10H,1H3

Upstream product

• 100-97-0 hexamethylenetetramine 
• 17288-40-3 5-methoxy-4-aza-1H-indole 
• 5467-69-6 6-methoxy-3-nitro-2-picoline 
• 111795-99-4 2-(6-methoxy-3-nitropyridin-2-yl)acetonitrile 
• 5446-92-4 2-methoxy-5-nitropyridine 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 1027068-77-4 5-oxo-4,5-dihydro-1H-pyrrolo<3,2-b>pyridine-3-carbaldehyde 

Relevant articles and documents

3-SUBSTITUTED-1H-INDOLE, 3-SUBSTITUTED-1H-PYRROLO[2,3-B]PYRIDINE AND 3-SUBSTITUTED-1H-PYRROLO[3,2-B]PYRIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES

The invention relates to 3-substituted-1H-indole, 3-substituted-1H-pyrrolo[2,3-b]pyridine, and 3-substituted-1H-pyrrolo[3,2-b]pyridine compounds of the Formula (I): or a pharmaceutically acceptable salt thereof, wherein the constituent variables are as defined herein, compositions comprising the compounds, and methods for making and using the compounds.

3-SUBSTITUTED-1H-PYRROLO[2,3-B]PYRIDINE AND 3-SUBSTITUTED-1H-PYRROLO[3,2-B]PYRIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES

The invention relates to 3-substituted-1H-pyrrolo[2,3-b]pyridine, and 3-substituted-1H-pyrrolo[3,2-b]pyridine compounds of the Formula 1: or a pharmaceutically acceptable salt thereof, wherein the constituent variables are as defined herein, compositions comprising the compounds, and methods for making and using the compounds.

PPAR ACTIVE COMPOUNDS

Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile.

Synthesis of new melatoninergic ligands including azaindole moiety

A novel series of melatonin analogues, based on the azaindole nucleus is described. These compounds are prepared in several steps directly from the commercial available 7-azaindole or from substituted amino-, iodo- or/and nitropyridines using a catalysed palladium reaction or vicarious nucleophilic substitution of hydrogen (VNS) in order to elaborate the 6-, 5- and 4- azaindole derivatives respectively.

The serotonin 5-HT4 receptor. 2. Structure-activity studies of the indole carbazimidamide class of agonists.

A number of substituted indole carbazimidamides were prepared and evaluated as 5-HT4 receptor agonists by using the isolated field-stimulated guinea pig ileum preparation. Their selectivity for the 5-HT4 receptor was established by examining their affinity for other 5-HT receptors using radioligand-binding techniques. Several selective and highly potent full as well as partial agonists emerged from this study. For example, 1b,d were found to be the most potent, full 5-HT4 receptor agonist described so far (EC50 = 0.5 and 0.8 nM, respectively), being 6 and 4 times more potent than serotonin itself. On the other hand, 5b and 1h appeared as partial 5-HT4 receptor agonists in the nonstimulated guinea pig ileum preparation with potencies, evaluated against serotonin action, respectively similar (5b, Ki = 12 nM) to and 300-fold higher (1h, Ki = 0.04 nM) than serotonin.