Welcome to LookChem.com Sign In|Join Free
  • or


Post Buying Request

100-97-0 Suppliers

Recommended suppliersmore

Product FOB Price Min.Order Supply Ability Supplier
Urotropine CAS NO.100-97-0
Cas No: 100-97-0
USD $ 1.0-3.0 / Kilogram 1 Kilogram 10 Kilogram/Day Hebei yanxi chemical co.,LTD. Contact Supplier
Fresh In Stock:Hexamine with BEST PRICE
Cas No: 100-97-0
USD $ 1.0-1.0 / Kilogram 1 Kilogram 20 Metric Ton/Day Scale Chemical Corporation Contact Supplier
Hexamethylenetetramine -- CHemwill
Cas No: 100-97-0
USD $ 1.0-1.0 / Metric Ton 1 Metric Ton 5 Metric Ton/Day Chemwill Asia Co., Ltd. Contact Supplier
High quality Hexamine supplier in China
Cas No: 100-97-0
No Data No Data No Data Simagchem Corporation Contact Supplier
Hexamethylenetetramine Manufacturer/High quality/Best price/In stock
Cas No: 100-97-0
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Hangzhou Dayangchem Co., Ltd. Contact Supplier
Hexamethylenetetramine CAS: 100-97-0
Cas No: 100-97-0
USD $ 1.0-2.0 / Metric Ton 5 Metric Ton 1000 Metric Ton/Year Henan Sinotech Import&Export Corporation Contact Supplier
Cas No: 100-97-0
No Data 100 Gram 100 Kilogram/Month HENAN SUNLAKE ENTERPRISE CORPORATION Contact Supplier
Cas No: 100-97-0
USD $ 20.0-20.0 / Gram 1 Gram 2000 Metric Ton/Month Jinan Finer Chemical Co., Ltd Contact Supplier
Pure quality 100-97-0 Hexamethylenetetramine
Cas No: 100-97-0
USD $ 1000.0-1500.0 / Kilogram 1 Kilogram 100 Metric Ton/Month Crovell Biotech (Hebei) Co., Ltd. Contact Supplier
Hexamethylenetetramine 100-97-0
Cas No: 100-97-0
No Data 1 Kilogram 1 Metric Ton/Day Henan Tianfu Chemical Co., Ltd. Contact Supplier

100-97-0 Usage

Chemical Properties

It is white hygroscopic crystalline powder or shiny colorless rhombic crystals. It is almost odorless with sweet and bitter taste. It is soluble in water and chloroform but less soluble in carbon tetrachloride, acetone, benzene and ether and insoluble in petroleum ether.
The above information is edited by the Chemicalbook of Dai Xiongfeng.

Air & Water Reactions

Highly flammable. Burns readily on contact with a flame with a smokeless flame. Finely powdered dust is significant dust explosion hazard. Water soluble.

Purification Methods

It is soluble in H2O (67%), CHCl3 (10%), EtOH (8%) and Et2O (0.3%), and a 0.2M solution has a pH of 8.4. Dissolve it in hot absolute EtOH (reflux, Norit), filter using a heated funnel, cool at room temperature first, then in ice. Wash the crystals with cold Et2O, dry them in air or under a vacuum. A further crop can be obtained by adding Et2O to the filtrate. It sublimes above 260o without melting. The picrate has m 179o(dec). [pK2 0 4.85: Reilley & Schmid Anal Chem 30 947 1958, pK2 0 6.30: Pummerer & Hofmann Chem Ber 56 1255 1923.] [Beilstein 26 I 306, 26 II 200, 26 III/IV 1680.]

Brand name

Uritone (Parke- Davis); Urotropin (Parke-Davis).

Pharmacological effects

It is a therapeutic drug for treating the bacterial urinary tract infections. Hexamethylenetetramine itself has no antibacterial effect. After oral absorption, it can be secreted out by renal with being broken down into ammonia and formaldehyde in acidic urine with the later one being able to effectively inhibit the G-bacteria, especially having a strong antibacterial effect on Escherichia coli, Enterobacter aerogenes and Pseudomonas aeruginosa. It can be used for treating urinary tract infections caused by susceptible strains. When it is subject to oral administration, the patients should also take vitamin C or ammonium chloride at the same time in order to acidify the urine (pH≤5.5).

Chemical Properties

Hexamethylenetetramine has an adamantane structure with high degree of symmetry and the characteristics of tertiary amines. Each of the four nitrogen atoms has a pair of unshared electron with being able to form coordination compound with many kinds of inorganic compounds. It can have heating reaction with strong inorganic acid to generate formaldehyde and ammonium salts. In the presence of zinc powder, it can have reaction with hydrochloric acid to generate the hydrochloride salt of trimethylamine and ammonium chloride. It can also be subject to nitrification and generate RDX. It can also have reaction with nitrous acid to form N'N'-Dinitroso pentamethylene tetramine. It can have reaction with hydrogen peroxide and hydrogen cyanide. It can also have reaction with sulfur and sulfur compounds or react with the alkali metal salts, alkaline earth metal, and rare earth metal salts to form a complex. In acidic medium, it can react with alcohol. It can also react with organic acid to form salt. It can also react with halides, phenols and amides as well as some natural products such as protein and fiber. It is irritating to the skin and can cause dermatitis. Intravenous-Rats LD50: 1200 mg/kg; Intraperitoneal injection-mice LD50: 512mg/kg.
the formula of hexamethylenetetramine
Figure 1 is the formula of hexamethylenetetramine

General Description

Odorless white crystalline powder or colorless lustrous crystals. Sublimes in a vacuum at about 505° F with some decomposition. Solutions are strong bases (pH of 0.2 molar aqueous solution is 8.4).


Used in the treatment of urinary track infection.

Reactivity Profile

Hexamethylenetetramine is hygroscopic. Hexamethylenetetramine is sensitive to exposure to heat. Hexamethylenetetramine is incompatible with oxidizing agents. Hexamethylenetetramine is also incompatible with acids. Hexamethylenetetramine reacts violently with sodium peroxide. Hexamethylenetetramine reacts explosively with 1-bromopentaborane(9) at temperatures above 194° F. The complex with iodine deflagrates at 280° F. The 1:1 addition complex with iodoform has exploded at 352° F. Hexamethylenetetramine is corrosive to some metals, such as aluminum and zinc . Special Hazards of Combustion Products: Formaldehyde gas and ammonia may be given off when hot [USCG, 1999].

Production method

It can be made from the condensation reaction of formaldehyde and ammonia. Place the formaldehyde solution in a reactor, put through the ammonia with condensation reaction being carried out in alkaline solution and the reaction temperature being maintained at 50-70 ℃; the material liquid was cooled and fed into the film vacuum evaporator and subject to evaporation at 60-80 ℃ to make its concentration be increased from 24% to 38%-42%. Then the reaction mixture was filtered and subjected to vacuum evaporation and crystallization, filtration drying to derive the hexamethylenetetramine product.
Put the formaldehyde (37% aqueous solution) and excess amount of ammonia for 3 h at 38 ℃. After completion of reaction, the reaction mixture was further subject to clarification, filtration, membrane evaporation (pressure 9.806~9.866 kPa) for twice with concentrated liquid subjecting cooling and crystallization, filtration, and drying at 150 ℃ to obtain the products. It is obtained through the reaction between formaldehyde and the calculated amount of ammonia.

Fire Hazard

Special Hazards of Combustion Products: Formaldehyde gas and ammonia may be given off when hot.


Hexamethylenetetramine is a versatile reagent in organic synthesis. It is used in the Duff reaction, the Sommelet reaction, and in the Delepine reaction.


antibacterial, tuberculostatic

Contact allergens

Hexamethylenetetramine is used in the foundry, tire and rubber, and phenol formaldehyde resins industries and in other applications such as a hardener in epoxy resins Bisphenol A type and as an anticorrosive agent. It is an ammonia and formaldehyde releaser sometimes used in topical medicaments and cosmetics

Chemical Properties

white crystalline powder


It can be used as the curing agent for resins and plastics, the vulcanization accelerator of rubber (accelerator H) and textiles shrink-proof agent. It can also be used for making antibacterial drug, explosives and so on. As medicine, after oral administration, it can be decomposed when coming across acidic urine to generate formaldehyde and exerts its antibacterial effect used for treating mild urinary tract infection; it can be externally used for treating ringworm, antiperspirants, and treatment of underarm odor. Its being mixed with caustic soda and sodium phenol can be used as the phosgene absorber of gas masks.
It can be used as a kind of anti-microbial agents.
It can be used as anti-shrinking textile finishing agent, bleaching agents of sodium chlorite and the buffer of waterproofing agents CR.
Hexamethylenetetramine is mainly used as the curing agent of plastic and resin, the catalyst and foaming agent of aminoplast, rubber vulcanization accelerator (accelerator H), and the shrink-proof agents of textiles. Hexamethylenetetramine is the raw material for organic synthesis and can be used for the production of chloramphenicol in the pharmaceutical industry. Hexamethylenetetramine can be used as the disinfectant of urinary system with itself having no antibacterial effect and being effective in treating gram-negative bacteria. Its 20% solution can be used for the treatment of underarm odor, sweaty feet, tinea and so on. Its being mixed with caustic soda and sodium phenol can be used as the phosgene absorber of gas masks. It can also be used for the manufacture of pesticides. Hexamethylenetetramine can react with fuming nitric acid to obtain highly explosive cyclonite, briefly referred as RDX. Hexamethylenetetramine can be used as the reagent and chromatography reagents for determination of bismuth, indium, manganese, cobalt, thorium, platinum, producing magnesium, lithium, copper, uranium, beryllium, tellurium, bromide, and iodide.
In the liver function tests, it can be used for formulating thymol turbidity, test and measurement of object such as bismuth, iron, manganese, cobalt, thorium, platinum and magnesium as well as the determination and identification of lithium, iron cyanide, iron bromide and iodide. It can also be used for the determination of copper, uranium, beryllium, tellurium etc. Moreover, it can be used as gas chromatography fixed solution (maximum usage temperature of 180 ℃ with the solvent being chloroform).


ChEBI: A polycyclic cage that is adamantane in which the carbon atoms at positions 1, 3, 5 and 7 are replaced by nitrogen atoms.

100-97-0 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Sigma-Aldrich (H11300)  Hexamethylenetetramine  ReagentPlus®, 99% 100-97-0 H11300-4KG 1,271.79CNY Detail
Sigma-Aldrich (H11300)  Hexamethylenetetramine  ReagentPlus®, 99% 100-97-0 H11300-1KG 552.24CNY Detail
Sigma-Aldrich (H11300)  Hexamethylenetetramine  ReagentPlus®, 99% 100-97-0 H11300-500G 398.97CNY Detail
Sigma-Aldrich (H11300)  Hexamethylenetetramine  ReagentPlus®, 99% 100-97-0 H11300-25G 358.02CNY Detail
Sigma-Aldrich (398160)  Hexamethylenetetramine  ACS reagent, ≥99.0% 100-97-0 398160-1KG 1,143.09CNY Detail
Sigma-Aldrich (398160)  Hexamethylenetetramine  ACS reagent, ≥99.0% 100-97-0 398160-250G 398.97CNY Detail
Sigma-Aldrich (398160)  Hexamethylenetetramine  ACS reagent, ≥99.0% 100-97-0 398160-5G 358.02CNY Detail
Sigma-Aldrich (Y0000754)  Methenamine  European Pharmacopoeia (EP) Reference Standard 100-97-0 Y0000754 1,880.19CNY Detail
Sigma-Aldrich (33233)  Hexamethylenetetramine  puriss. p.a., Reag. Ph. Eur., ≥99.5% (calc. to the dried substance) 100-97-0 33233-1KG-R 1,730.43CNY Detail
Sigma-Aldrich (33233)  Hexamethylenetetramine  puriss. p.a., Reag. Ph. Eur., ≥99.5% (calc. to the dried substance) 100-97-0 33233-500G-R 1,240.20CNY Detail
Sigma-Aldrich (33233)  Hexamethylenetetramine  puriss. p.a., Reag. Ph. Eur., ≥99.5% (calc. to the dried substance) 100-97-0 33233-100G-R 441.09CNY Detail
Alfa Aesar (A17213)  Hexamethylenetetramine, 99+%    100-97-0 5000g 932.0CNY Detail



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017


1.1 GHS Product identifier

Product name hexamethylenetetramine

1.2 Other means of identification

Product number -
Other names Hexamethylenetet

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Food additives
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:100-97-0 SDS

100-97-0Related news

Unusual behavior of temperature-dependent solvent H/D isotope effects in the enthalpy and heat capacity of Hexamethylenetetramine (cas 100-97-0) (urotropine) hydration07/20/2019

Based on the identified inconsistencies in the existing literature data on the enthalpies and heat capacities of dissolution (solvation) of hexamethylenetetramine (HMTA) in ordinary (H2O) and heavy (D2O) water, we carried out carefully the calorimetric study of these two binary systems at seven ...detailed

Effect of Hexamethylenetetramine (cas 100-97-0) on the property of Chinese lacquer film07/19/2019

Hexamethylenetetramine (HMTA) was used to modify the raw Chinese lacquer and the film was characterized by using Fourier transform infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA) and scanning electron microscopy (SEM). The results show that the property of the Chinese lacquer fil...detailed

Please post your buying leads,so that our qualified suppliers will soon contact you!

*Required Fields