173095-00-6Relevant articles and documents
Improvement of the Ullmann's condensation method for the synthesis of 2-anilinonicotinic acids
Misbahi, Houria,Brouant, Pierre,Barbe, Jacques
, p. 335 - 336 (2007/10/03)
Several 2-anilinonicotinic acid derivatives were prepared under the Ullmann's reaction conditions by condensation of 2-chloronicotinic acid and various substituted anilines. Improvement of the procedure based on the effect of the catalyst and that of the
Potential Anticancer Benzo-naphthyridones with Fused Rings: a Theoretical Model for Predicting Orientation in the Cyclization of Intermediates
Mefetah, Hafid,Brouant, Pierre,Galy, Anne-Marie,Galy, Jean-Pierre,Barbe, Jacques
, p. 522 - 533 (2007/10/03)
Synthesis of benzo[b]-1,8-naphthyridine-5-ones with fused ring from halonicotinic acids and amino-substituted benzoheterocycles, leads either to an isomeric mixture or to single isomers. MO calculations conducted on the starting amino-substituted benzoheterocycles, allow predictions of the derivative(s) to be obtained. Some selected compounds belonging to this series were screened in vitro against several human tumor cell lines.