A series of new acridines has been prepared by cyclodehydration of N-(2,3-dihydro-1,4-benzodioxin-6-yl)anthranilic acid in acidic media following classical procedures. All these compounds have in common a dioxygenated ring fused to the acridine. The tetra
Sánchez, Isabel,Reches, Rosa,Caignard, Daniel Henry,Renard, Pierre,Pujol, Maria Dolors
p. 340 - 352
(2007/10/03)
Potential Anticancer Benzo-naphthyridones with Fused Rings: a Theoretical Model for Predicting Orientation in the Cyclization of Intermediates
Synthesis of benzo[b]-1,8-naphthyridine-5-ones with fused ring from halonicotinic acids and amino-substituted benzoheterocycles, leads either to an isomeric mixture or to single isomers. MO calculations conducted on the starting amino-substituted benzoheterocycles, allow predictions of the derivative(s) to be obtained. Some selected compounds belonging to this series were screened in vitro against several human tumor cell lines.
Mefetah, Hafid,Brouant, Pierre,Galy, Anne-Marie,Galy, Jean-Pierre,Barbe, Jacques
p. 522 - 533
(2007/10/03)
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