173095-01-7Relevant articles and documents
Synthesis and?biological evaluation of?modified acridines: the?effect of?N- and?O- substituent in?the?nitrogenated ring on?antitumor activity
Sánchez, Isabel,Reches, Rosa,Caignard, Daniel Henry,Renard, Pierre,Pujol, Maria Dolors
, p. 340 - 352 (2007/10/03)
A series of new acridines has been prepared by cyclodehydration of N-(2,3-dihydro-1,4-benzodioxin-6-yl)anthranilic acid in acidic media following classical procedures. All these compounds have in common a dioxygenated ring fused to the acridine. The tetra
Potential Anticancer Benzo-naphthyridones with Fused Rings: a Theoretical Model for Predicting Orientation in the Cyclization of Intermediates
Mefetah, Hafid,Brouant, Pierre,Galy, Anne-Marie,Galy, Jean-Pierre,Barbe, Jacques
, p. 522 - 533 (2007/10/03)
Synthesis of benzo[b]-1,8-naphthyridine-5-ones with fused ring from halonicotinic acids and amino-substituted benzoheterocycles, leads either to an isomeric mixture or to single isomers. MO calculations conducted on the starting amino-substituted benzoheterocycles, allow predictions of the derivative(s) to be obtained. Some selected compounds belonging to this series were screened in vitro against several human tumor cell lines.