173154-00-2

Basic information

• Product Name: (S)-4-Benzyl-3-((S)2-((R) -2-BroMo-2((2S,4S)-4-isopropyl-5- oxo-tetrahydro-furan-2-yl)-3-Methyl-butyryl)-oxaxolidin-2-one
• Synonyms: (S)-4-Benzyl-3-((S)2-((R) -2-BroMo-2((2S,4S)-4-isopropyl-5- oxo-tetrahydro-furan-2-yl)-3-Methyl-butyryl)-oxaxolidin-2-one;2-Oxazolidinone,3-[(2S,4R)-4-bromo-2-(1-methylethyl)-1-oxo-4-[(2S,4S)-tetrahydro-4-(1-methylethyl)-5-oxo-2-furanyl]butyl]-4-(phenylmethyl)-, (4S)-;(4S)-4-benzyl-3-[(2S,4R)-4-bromo-2-isopropyl-4-[(2S,4S)-4-isopropyl-5-oxo-tetrahydrofuran-2-yl]butanoyl]oxazolidin-2-one;3(S)-Isopropyl-5(S)-{1 (R)-bromo-4-methyl-3(S)-[(4(S)-benzyloxazolidin-2-on-3-yl)-carbonyl]-pentyl}-tetrahydrofuran-2-one
• CAS NO: 173154-00-2
• Molecular Formula: C₂₄H₃₂BrNO₅
• Molecular Weight: 494.41858
• EINECS: 1312995-182-4
• Product Categories: aliskiren
• Mol File: 173154-00-2.mol

Chemical Properties

• Melting Point: 91.2 °C
• Boiling Point: 626.2°C at 760 mmHg
• Flash Point: 332.5°C
• Appearance: /
• Density: 1.315g/cm³
• Vapor Pressure: 1.35E-15mmHg at 25°C
• Refractive Index: 1.553
• PKA: -2.37±0.40(Predicted)
• CAS DataBase Reference: (S)-4-Benzyl-3-((S)2-((R) -2-BroMo-2((2S,4S)-4-isopropyl-5- oxo-tetrahydro-furan-2-yl)-3-Methyl-butyryl)-oxaxolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-4-Benzyl-3-((S)2-((R) -2-BroMo-2((2S,4S)-4-isopropyl-5- oxo-tetrahydro-furan-2-yl)-3-Methyl-butyryl)-oxaxolidin-2-one(173154-00-2)
• EPA Substance Registry System: (S)-4-Benzyl-3-((S)2-((R) -2-BroMo-2((2S,4S)-4-isopropyl-5- oxo-tetrahydro-furan-2-yl)-3-Methyl-butyryl)-oxaxolidin-2-one(173154-00-2)

Safety Data

• Hazardous Substances Data: 173154-00-2(Hazardous Substances Data)

Usage

Uses

Used in Organic Chemistry:
(S)-4-Benzyl-3-((S)2-((R) -2-BroMo-2((2S,4S)-4-isopropyl-5-oxo-tetrahydro-furan-2-yl)-3-Methyl-butyryl)-oxaxolidin-2-one is used as a building block or intermediate in the synthesis of various organic compounds. Its unique structure and functional groups make it a valuable component in the development of new molecules with specific properties and reactivity.
Used in Pharmaceutical Industry:
(S)-4-Benzyl-3-((S)2-((R) -2-BroMo-2((2S,4S)-4-isopropyl-5-oxo-tetrahydro-furan-2-yl)-3-Methyl-butyryl)-oxaxolidin-2-one is used as a potential drug candidate or a key component in the development of pharmaceutical agents. Its complex structure and chiral centers may contribute to its biological activity and selectivity, making it a promising candidate for the treatment of various diseases and conditions.
Used in Material Science:
(S)-4-Benzyl-3-((S)2-((R) -2-BroMo-2((2S,4S)-4-isopropyl-5-oxo-tetrahydro-furan-2-yl)-3-Methyl-butyryl)-oxaxolidin-2-one is used as a component in the development of advanced materials with specific properties. Its unique structure and functional groups can be utilized to create materials with tailored characteristics, such as improved stability, reactivity, or selectivity, for various applications in different industries.

InChI:InChI=1/C24H32BrNO5/c1-14(2)18(11-20(25)21-12-19(15(3)4)23(28)31-21)22(27)26-17(13-30-24(26)29)10-16-8-6-5-7-9-16/h5-9,14-15,17-21H,10-13H2,1-4H3/t17-,18-,19-,20+,21-/m0/s1

Upstream product

• 90719-32-7 (S)-4-Benzyl-2-oxazolidinone 
• 108-12-3 isopentanoyl chloride 
• 145589-03-3 (S)-4-benzyl-3-(3-methylbutanoyl)oxazolidin-2-one 

Downstream Products

• 173154-01-3 (S)-3-((2S,4S)-4-azido-2-isopropyl-4-((2S,4S)-4-isopropyl-5-oxotetrahydrofuran-2-yl)butanoyl)-4-benzyloxazolidin-2-one 
• 934841-17-5 (3S,5S)-tert-butyl-3-isopropyl-5-((2S,4S)-4-isopropyl-5-oxotetrahydrofuran-2-yl)-2-oxopyrrolidine-1-carboxylate 
• 934841-30-2 (3S,5S)-3-isopropyl-5-((2S,4S)-4-isopropyl-5-oxo-tetrahydro-furan-2-yl)pyrrolidin-2-one 
• 90719-32-7 (S)-4-Benzyl-2-oxazolidinone 

Relevant articles and documents

A Facile, Six-Step Process for the Synthesis of (3 S,5 S)-3-Isopropyl-5-((2 S,4 S)-4-isopropyl-5-oxo-tetrahydrofuran-2-yl)-2-oxopyrrolidine-1-carboxylic Acid tert -Butyl Ester, the Key Synthetic Intermediate of Aliskiren

A facile, six-step process for the synthesis of (3S,5S)-3-isopropyl-5-((2S,4S)-4-isopropyl-5-oxotetrahydro- furan-2-yl)-2-oxopyrrolidine-1-carboxylic acid tert-butyl ester from (S)-4-benzyloxazolidin-2-one 2 in an overall 50% yield is reported. The key transformations include: a highly efficient diastereoselective epoxidation, Lewis acid-catalyzed ring-opening with bromide, an SN2 reaction using NaN3, and a tandem reduction-cyclization reaction.

METHODS OF TREATING ALZHEIMER'S DISEASE USING ARYL ALKANOIC ACID AMIDES

Disclosed are methods for treating Alzheimer’s disease, and other diseases, and/or inhibiting beta-secretase enzyme, and/or inhibiting deposition of A beta peptide in a mammal, by use of compounds of formula 1 (1) wherein the variables R1-R8 and X are defined herein.