The 2,4-dimethylpent-3-yloxycarbonyl (Doc) group as a new, nucleophile-resistant protecting group for tyrosine in solid phase peptide synthesis
The 2,4-dimethylpent-3-yloxycarbonyl (Doc) group is presented as a new protecting group for tyrosine. The Doc group is 1000-fold more stable towards the nucleophile piperidine than the commonly used 2-bromobenzyloxycarbonyl (2-BrZ) group is, and it is completely cleaved by hydrogen fluoride.