The 2,4-dimethylpent-3-yloxycarbonyl (Doc) group as a new, nucleophile-resistant protecting group for tyrosine in solid phase peptide synthesis

DOI: 10.1016/S0040-4039(96)02471-9

Source and publish data:

Tetrahedron Letters p. 1075 - 1078 (1997)

Update date:2022-08-02

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Authors:

Rosenthal, Katri

Karlstroem, Amelie

Unden, Anders

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Article abstract of DOI:10.1016/S0040-4039(96)02471-9

The 2,4-dimethylpent-3-yloxycarbonyl (Doc) group is presented as a new protecting group for tyrosine. The Doc group is 1000-fold more stable towards the nucleophile piperidine than the commonly used 2-bromobenzyloxycarbonyl (2-BrZ) group is, and it is completely cleaved by hydrogen fluoride.

Full text of DOI:10.1016/S0040-4039(96)02471-9

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