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t-Butyl 3-iodobenzoate is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 173406-17-2 Structure
  • Basic information

    1. Product Name: t-Butyl 3-iodobenzoate
    2. Synonyms: t-Butyl 3-iodobenzoate;tert-Butyl 3-iodobenzoate
    3. CAS NO:173406-17-2
    4. Molecular Formula: C11H13IO2
    5. Molecular Weight: 304.12419
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 173406-17-2.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 316.8±25.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.528±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C(protect from light)
    8. Solubility: N/A
    9. CAS DataBase Reference: t-Butyl 3-iodobenzoate(CAS DataBase Reference)
    10. NIST Chemistry Reference: t-Butyl 3-iodobenzoate(173406-17-2)
    11. EPA Substance Registry System: t-Butyl 3-iodobenzoate(173406-17-2)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 173406-17-2(Hazardous Substances Data)

173406-17-2 Usage

Uses

tert-Butyl 3-iodobenzoate is a useful reactant for the synthesis of (aryl)cycloalkanones.

Check Digit Verification of cas no

The CAS Registry Mumber 173406-17-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,3,4,0 and 6 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 173406-17:
(8*1)+(7*7)+(6*3)+(5*4)+(4*0)+(3*6)+(2*1)+(1*7)=122
122 % 10 = 2
So 173406-17-2 is a valid CAS Registry Number.

173406-17-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name tert-Butyl 3-iodobenzoate

1.2 Other means of identification

Product number -
Other names tert-butyl m-iodobenzoate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:173406-17-2 SDS

173406-17-2Relevant articles and documents

Compounds and methods of use

-

Page/Page column 474-475, (2021/08/04)

Compounds are provided according to Formula (I): and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein X1, X2, X3, X4, Y, A, L1, L2, R1, R2, R5, m and n are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of conditions.

Rapid Organocatalytic Formation of Carbon Monoxide: Application towards Carbonylative Cross Couplings

Zoller, Ben,Zapp, Josef,Huy, Peter H.

supporting information, p. 9632 - 9638 (2020/07/13)

Herein, the first organocatalytic method for the transformation of non-derivatized formic acid into carbon monoxide (CO) is introduced. Formylpyrrolidine (FPyr) and trichlorotriazine (TCT), which is a cost-efficient commodity chemical, enable this decarbonylation. Utilization of dimethylformamide (DMF) as solvent and catalyst even allows for a rapid CO generation at room temperature. Application towards four different carbonylative cross coupling protocols demonstrates the high synthetic utility and versatility of the new approach. Remarkably, this also comprehends a carbonylative Sonogashira reaction at room temperature employing intrinsically difficult electron-deficient aryl iodides. Commercial 13C-enriched formic acid facilitates the production of radiolabeled compounds as exemplified by the pharmaceutical Moclobemide. Finally, comparative experiments verified that the present method is highly superior to other protocols for the activation of carboxylic acids.

FAK AND FLT3 INHIBITORS

-

Page/Page column 62, (2014/03/22)

The use of a compound of the formula (I): (Formula (I)) in the preparation of a medicament for treating Acute Myeloid Leukemia or a disease ameliorated by the inhibition of Flt3, or Flt3 and FAK.

KINASE INHIBITORS

-

Paragraph 0-453, (2013/09/26)

The present invention relates to compounds of formulae I and II wherein the variables are as defined herein. These compounds are capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.

METHOD OF TREATING CONDITIIONS WITH KINASE INHIBITORS

-

Paragraph 0437-0438, (2013/09/26)

The present invention relates to a method of treating ophthalmic diseases and conditions, e.g. diabetic retinopathy, age-related macular degeneration, retinopathy of prematurity, etc., in a subject comprising administering to said subject a therapeutically effective amount of at least one compound of formula I or a prodrug, pharmaceutically acceptable salt, racemic mixtures or enantiomers of said compound. The compounds of formula I are capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.

FAK INHIBITORS

-

Page/Page column 58; 60, (2012/09/10)

A compound of the formula (I): where R1 or R2 is a cycle amine group and R5 is an aromatic group with a carbonyl containing substituent for use as a FAK inhibitor.

Configurationally stable propeller-like triarylphosphine and triarylphosphine oxide

Pinter, Aron,Haberhauer, Gebhard,Hyla-Kryspin, Isabella,Grimme, Stefan

, p. 3711 - 3713 (2008/03/14)

Configurationally stable, propeller-like triarylphosphine and triarylphosphine oxide can be synthesized; a chiral scaffold based on Lissoclinum-cyclopeptides linked via three peptide bonds with a triphenylphosphine and triphenylphosphine oxide moiety, respectively, prevents effectively epimerization at the chiral phosphorus atom. The Royal Society of Chemistry.

Abc amino acids: Design, synthesis, and properties of new photoelastic amino acids

Standaert, Robert F.,Park, Seung Bum

, p. 7952 - 7966 (2007/10/03)

Photoisomerizable amino acids provide a direct avenue to the experimental manipulation of bioactive polypeptides, potentially allowing real-time, remote control of biological systems and enabling useful applications in nanobiotechnology. Herein, we report a new class of photoisomerizable amino acids intended to cause pronounced expansion and contraction in the polypeptide backbone, i.e., to be photoelastic. These compounds, termed Abe amino acids, employ a photoisomerizable azobiphenyl chromophore to control the relative disposition of aminomethyl and carboxyl substituents. Molecular modeling of nine Abc isomers led to the identification of one with particularly attractive properties, including the ability to induce contractions up to 13 A in the backbone upon trans → cis photoisomerization. This isomer, designated mpAbc, has substituents at meta and para positions on the inner (azo-linked) and outer rings, respectively. An efficient synthesis of Fmoc-protected mpAbc was executed in which the biaryl components were formed via Suzuki couplings and the azo linkage was formed via amine/nitroso condensation; protected forms of three other Abc isomers were prepared similarly. An undecapeptide incorporating mpAbc was synthesized by conventional solid-phase methods and displayed characteristic azobenzene photochemical behavior with optimal conversion to the cis isomer at 360 nm and a thermal cis → trans half-life of 100 min at 80 °C.

Discovery of Small-Molecule Inhibitors of the ATPase Activity of Human Papillomavirus E1 Helicase

Faucher, Anne-Marie,White, Peter W.,Brochu, Christian,Grand-Ma?tre, Chantal,Rancourt, Jean,Fazal, Gulrez

, p. 18 - 21 (2007/10/03)

The Boehringer Ingelheim compound collection was screened for inhibitors of the ATPase activity of human papillomavirus E1 helicase to develop antiviral agents that inhibit human papillomavirus (HPV) DNA replication. This screen led to the discovery of (biphenyl-4-sulfonyl)acetic acid 1, which inhibits the ATPase activity of HPV type 6 E1 helicase with a low micromolar IC50 value. A hit-to-lead exercise rapidly converted 1 into a low nanomolar lead series.

Alpha-substituted thio,-oxo trifluoromethylketones as phospholipase inhibitors

-

, (2008/06/13)

Inhibitors of the cytosolic phospholypase A2 enzymes are provided which are of use in controlling a wide variety of inflammatory diseases. The inhibitors of the present invention have the general formula where X, Z, X1, R1, R2/

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