- A microwave-assisted synthesis of (S)-N-protected homoserine γ-lactones from l-aspartic acid
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A three-pot preparation of (S)-N-protected homoserine γ-lactones is presented. Conversion of N-protected l-aspartic acid to an oxazolidinone is followed by selective reduction/acid-catalyzed cyclization to deliver the lactones. Microwave irradiation proved valuable for improving the latter reaction steps in some cases.
- Singh, Suneel P.,Michaelides, Alex,Merrill, A. Rod,Schwan, Adrian L.
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p. 6825 - 6831
(2011/10/08)
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- Lactam-conformationally restricted analogs of N(α)-arylsulfonyl arginine amide: Design, synthesis and inhibitory activity toward thrombin and related enzymes
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Three new lactam-conformationally restricted arginine derivatives, 1- butyl-3-(6,7-dimethoxy-2-naphthylsulfonyl)-3-(3-guanidinopropyl)-substituted γ-, δ-, and ε-lactams (2-4), were synthesized on the basis of backbone modification of the lead structure, 6
- Okayama,Seki,Ito,Takeshima,Hagiwara,Morikawa
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p. 1683 - 1691
(2007/10/03)
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