- Intramolecular Cyclization of Vinyldiazoacetates as a Versatile Route to Substituted Pyrazoles
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Vinyldiazo compounds undergo a thermal electrocyclization to form pyrazoles in yields of up to 95percent. The reactions are operationally simple, use readily available starting materials, require no intervention of a catalyst, and enable the synthesis of mono-, di- A nd tri-substituted pyrazoles. With the ability to produce highly substituted pyrazoles and the flexibility in installing various types of substituents, this method constitutes a new entry to this valuable heterocyclic scaffold and may be of interest to all branches of the chemical industry.
- Drikermann, Denis,G?rls, Helmar,Kerndl, Valerie,Vilotijevic, Ivan
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p. 1158 - 1162
(2020/07/20)
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- SYNTHESIS OF β-HYDROXYALKYLPYRAZOLES BY REACTION OF β-ARYLACRYLOYLOXIRANES WITH HYDRAZINE
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Reaction of β-arylacryloyloxiranes with hydrazine hydrate takes place via intermediate α,β-epoxyalkylpyrazoles which then undergo intramolecular oxidative-reductive disproportionation to yield β-hydroxyalkylpyrazoles.
- Zvonok, A. M.,Kuz'menok, N. M.,Stanishevskii, L. S.
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p. 534 - 537
(2007/10/02)
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