17357-78-7

Upstream product

• 130657-28-2 2-(5-Phenyl-1H-pyrazol-3-yl)-propan-1-ol 
• 41108-92-3 3,3-diacetyl-1-phenyl-1-propylene 
• 877-94-1 phenyl-5 pentene-4 one-2 
• 134418-83-0 (E)-3-diazo-5-phenylpent-4-en-2-one 
• 122-78-1 phenylacetaldehyde 

Relevant academic research and scientific papers

Intramolecular Cyclization of Vinyldiazoacetates as a Versatile Route to Substituted Pyrazoles

Vinyldiazo compounds undergo a thermal electrocyclization to form pyrazoles in yields of up to 95percent. The reactions are operationally simple, use readily available starting materials, require no intervention of a catalyst, and enable the synthesis of mono-, di- A nd tri-substituted pyrazoles. With the ability to produce highly substituted pyrazoles and the flexibility in installing various types of substituents, this method constitutes a new entry to this valuable heterocyclic scaffold and may be of interest to all branches of the chemical industry.

SYNTHESIS OF β-HYDROXYALKYLPYRAZOLES BY REACTION OF β-ARYLACRYLOYLOXIRANES WITH HYDRAZINE

Reaction of β-arylacryloyloxiranes with hydrazine hydrate takes place via intermediate α,β-epoxyalkylpyrazoles which then undergo intramolecular oxidative-reductive disproportionation to yield β-hydroxyalkylpyrazoles.