173903-19-0Relevant articles and documents
Preparation method of indoxacarb key intermediate
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Paragraph 0030; 0032; 0036; 0038; 0042; 0044; 0048; 0050, (2020/07/02)
The invention belongs to the field of chemical synthesis, and relates to a novel preparation method of an indoxacarb key intermediate. In the cyclization reaction process of the key intermediate synthesis method, paraformaldehyde substances are adopted to replace original diethoxymethane, generation of by-product ethanol in the reaction process is avoided, generation of ethyl ester impurities is effectively inhibited, generation of a mixed solvent is eliminated, the environmental protection pressure is reduced, the production cost is greatly reduced while the quality of the intermediate is improved, and a good foundation is laid for production of high-quality indoxacarb.
Preparation method of indoxacarb key intermediate
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Paragraph 0007; 0025-0028; 0031-0034; 0037-0040; 0043-0046, (2020/11/05)
The invention belongs to the field of chemical synthesis, and relates to a novel method for preparing an indoxacarb key intermediate. The key intermediate is 7-indeno [1, 2, e] [1, 3, 4] oxadiazine-2,4a (3H, 5H)-dicarboxylic acid-4a-methyl ester-2-benzyl ester. The preparation method is mainly characterized in that a phase transfer catalyst is added in the condensation reaction process, reactantsare in full contact under the action of the phase transfer catalyst, so that the reaction quickly realizes a homogeneous system, the reaction is more thorough, the product yield is high, the reactiontime is shortened by about 3-4 hours compared with the existing process, and the reaction rate is greatly improved. More importantly, the condensation system is a homogeneous system, is easy to dropwise add in the cyclization reaction process, does not block a bottom valve or a pipeline, is convenient to operate, saves manpower and material resources, and is beneficial to industrial production.
Visible Light-Induced Salan-Copper(II)-Catalyzed Enantioselective Aerobic α-Hydroxylation of β-Keto Esters
Yang, Fan,Zhao, Jingnan,Tang, Xiaofei,Wu, Yufeng,Yu, Zongyi,Meng, Qingwei
supporting information, p. 1673 - 1677 (2019/02/26)
A strategy of visible light-induced salan-copper(II)-catalyzed asymmetric α-hydroxylation of β-keto ester with utilization of sustainable air as the oxidant was developed. This protocol allows convenient access to a number of enantioenriched α-hydroxyl β-keto esters (up to 95% yield, 96% ee), especially for β-keto methyl esters that are valuable architectures in pharmaceuticals, including the key intermediate of the sodium-channel blocker (S)-indoxacarb. Experimental studies suggest that reactive singlet oxygen may participate in this reaction. (Figure presented.).
Preparation method of indoxacarb intermediate
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Paragraph 0027-0050, (2019/05/08)
The invention discloses a preparation method of an indoxacarb intermediate. An intermediate 5-chloro-2-methoxycarbonyl-2-hydroxy-1-indanone and benzyl carbazate are used as starting materials, a reaction is completed in the presence of a catalyst and a so
Indeno oxadiazine compound synthetic method
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Paragraph 0032; 0047-0064, (2019/01/08)
The invention relates to an indeno oxadiazine compound synthetic method. The method comprises the following steps: mixing toluene, methyl 5-chloro-2,3-dihydro-2-hydroxy-1-oxo-inden-2-carboxylate, benzyl carbazate and methylbenzenesulfonic acid, performing
Asymmetric α-Hydroxylation of β-Indanone Esters and β-Indanone Amides Catalyzed by C-2′ Substituted Cinchona Alkaloid Derivatives
Wang, Yakun,Yin, Hang,Qing, Hai,Zhao, Jingnan,Wu, Yufeng,Meng, Qingwei
supporting information, p. 737 - 745 (2016/03/09)
The highly catalytic asymmetric α-hydroxylation of β-indanone esters and β-indanone amides using peroxide as the oxidant was realized with a new C-2′ substituted Cinchona alkaloid derivatives. The two enantiomers of α-hydroxy-β-indanone esters could be obtained by simply changing the oxidant. This protocol allows a convenient access to the corresponding α-hydroxy-β-indanone esters and α-hydroxy-β-indanone amides with up to 99% yield and 98% ee.