65738-56-9

Basic information

• Product Name: methyl 5-chloro-1-oxo-2,3-dihydro-1H-indene-2-carboxylate
• Synonyms: methyl 5-chloro-1-oxo-2,3-dihydro-1H-indene-2-carboxylate
• CAS NO: 65738-56-9
• Molecular Formula: C₁₁H₉ClO₃
• Molecular Weight: 224.64036
• Mol File: 65738-56-9.mol
• Article Data: 30

Chemical Properties

• Boiling Point: 346.015°C at 760 mmHg
• Flash Point: 150.575°C
• Appearance: /
• Density: 1.365g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.575
• Solubility: Chloroform; Dichloromethane; DMSO; Ethyl Acetate
• PKA: 9.87±0.20(Predicted)
• CAS DataBase Reference: methyl 5-chloro-1-oxo-2,3-dihydro-1H-indene-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 5-chloro-1-oxo-2,3-dihydro-1H-indene-2-carboxylate(65738-56-9)
• EPA Substance Registry System: methyl 5-chloro-1-oxo-2,3-dihydro-1H-indene-2-carboxylate(65738-56-9)

Safety Data

• Hazardous Substances Data: 65738-56-9(Hazardous Substances Data)

Usage

Uses

Methyl 5-Chloro-1-oxo-2,3-dihydro-1H-indene-2-carboxylate is an intermediate in the synthesis of IN-KG 433 (I627995) which is an impurity of Indoxacarb (I654000), an oxadiazine pesticide that acts against lepidopteran larvae and is the active ingredient in a number of household insecticides including cockroach baits.

InChI:InChI=1/C11H9ClO3/c1-15-11(14)9-5-6-4-7(12)2-3-8(6)10(9)13/h2-4,9H,5H2,1H3

Upstream product

• 42348-86-7 5-chloro-1-indanone 
• 1579-14-2 2-chloroindanone 
• 616-38-6 carbonic acid dimethyl ester 
• 122-01-0 4-chloro-benzoyl chloride 
• 292638-85-8 acrylic acid methyl ester 
• 103040-43-3 3-(3-chlorophenyl)propionic acid methyl ester 
• 42175-03-1 methyl ester of m-chlorocinnamic acid 
• 108-90-7 chlorobenzene 
• 3946-29-0 3,4'-Dichloropropiophenone 
• 252989-39-2 methyl 4-chloro-2-(3-methoxy-3-oxo-1-propanyl)-benzoate 

Downstream Products

• 871682-78-9 tert-butyl 5-chloro-1-oxo-2,3-dihydro-1H-indene-2-carboxylate 
• 876727-36-5 (R)-methyl 5-chloro-1-oxo-2-(3-oxobutyl)-2,3-dihydro-1H-indene-2-carboxylate 
• 1173425-26-7 (R)-methyl 7-chloro-3-oxo-2,3,9,9a-tetrahydro-1H-fluorene-9a-carboxylate 
• 1261666-08-3 adamantyl 5-chloro-2,3-dihydro-1-oxo-1H-indene-2-carboxylate 
• 1429880-49-8 (R)-tert-butyl 5-chloro-1-oxo-2-(9H-xanthen-9-yl)-2,3-dihydro-1H-indene-2-carboxylate 
• 1429880-75-0 tert-butyl 5-chloro-1-oxo-2-(9H-xanthen-9-yl)-2,3-dihydro-1H-indene-2-carboxylate 
• 1280485-99-5 (S)-methyl 5-chloro-2-fluoro-1-oxo-2,3-dihydro-1H-indene-2-carboxylate 
• 1332702-57-4 methyl 5-chloro-1-oxo-2-(trifluoromethyl)-2,3-dihydro-1H-indene-2-carboxylate 

Relevant articles and documents

Enecarbamates as imine surrogates: Nucleophilic addition of 1,3-dicarbonyl compounds to enecarbamates

(Chemical Equation Presented) Novel Mannich-type reactions of 1,3-dicarbonyl compounds with enecarbamates have been developed. Stable and storable enecarbamates work as surrogates of aliphatic aldehyde-derived imines, which are known to be difficult to isolate and store.

Method for synthesizing methyl 6-chloro-3-oxo-1,2-dihydroindene-2-carboxylate by one-pot method

The invention discloses a method for synthesizing methyl 6-chloro-3-oxo-1,2-dihydroindene-2-carboxylate by one-pot method, thereby overcoming the technical defects of long synthesis route, multiple reaction steps, multiple generated three wastes, high difficulty in subsequent three waste treatment and the like in the prior art. methyl 6-chloro-3-oxo-1,2-dihydroindene-2-carboxylate is synthesizedfrom a substrate parachlorobenzoyl chloride and methyl acrylate by a one-pot method under the effect of lewis acid. A one-pot synthesis reaction is adopted, the reaction steps are few, operation is easy, raw materials are easy to obtain, and the method is economical, environmentally friendly and suitable for the current environmental protection requirement.

Highly Carbon-Selective Monofluoromethylation of β-Ketoesters with Fluoromethyl Iodide

A highly carbon-selective monofluoromethylation of a broad range of β-ketoesters with fluoromethyl iodide under mild conditions is described. The uses of lithium tert-butoxide as the base and diglyme as the solvent made great contributions to the high C/O regioselectivity.