173989-76-9

Basic information

• Product Name: (R)-1-(1-phenylethyl)-1H-Pyrrole-2-carboxylicacid
• Synonyms: (R)-1-(1-phenylethyl)-1H-Pyrrole-2-carboxylicacid
• CAS NO: 173989-76-9
• Molecular Formula: C13H13NO2
• Molecular Weight: 215.24782
• Mol File: 173989-76-9.mol

Chemical Properties

• Boiling Point: 373.416°C at 760 mmHg
• Flash Point: 179.636°C
• Appearance: /
• Density: 1.137g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.578
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (R)-1-(1-phenylethyl)-1H-Pyrrole-2-carboxylicacid(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-(1-phenylethyl)-1H-Pyrrole-2-carboxylicacid(173989-76-9)
• EPA Substance Registry System: (R)-1-(1-phenylethyl)-1H-Pyrrole-2-carboxylicacid(173989-76-9)

Safety Data

• Hazardous Substances Data: 173989-76-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
(R)-1-(1-phenylethyl)-1H-Pyrrole-2-carboxylic acid is used as a key intermediate in the synthesis of various pharmaceuticals and biologically active compounds. Its unique structure allows for the creation of novel molecules with potential therapeutic applications.
Used in Antifungal and Antibacterial Applications:
In the field of infectious diseases, (R)-1-(1-phenylethyl)-1H-Pyrrole-2-carboxylic acid is used as an active agent for the development of new antifungal and antibacterial drugs. Its potential to modulate biological processes makes it a promising candidate for combating resistant strains of bacteria and fungi.
Used in Biological Research:
(R)-1-(1-phenylethyl)-1H-Pyrrole-2-carboxylic acid is used as a research tool to study the modulation of certain biological processes. Understanding its interactions with biological systems can lead to the discovery of new therapeutic targets and strategies.
Used in Material Science:
In the field of material science, (R)-1-(1-phenylethyl)-1H-Pyrrole-2-carboxylic acid is used as a building block for the synthesis of complex organic compounds. Its unique properties may contribute to the development of new materials with specific characteristics and applications.
Used in Chemical Synthesis:
(R)-1-(1-phenylethyl)-1H-Pyrrole-2-carboxylic acid is used as a versatile starting material in chemical synthesis, particularly for the creation of complex organic molecules with potential applications in various industries, including pharmaceuticals, agrochemicals, and specialty chemicals.

InChI:InChI=1/C13H13NO2/c1-10(11-6-3-2-4-7-11)14-9-5-8-12(14)13(15)16/h2-10H,1H3,(H,15,16)/t10-/m1/s1

Upstream product

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Relevant articles and documents

Structure-activity relationship and liver microsome stability studies of pyrrole necroptosis inhibitors

Necroptosis is a regulated caspase-independent cell death pathway resulting in morphology reminiscent of passive non-regulated necrosis. Several diverse structure classes of necroptosis inhibitors have been reported to date, including a series of [1,2,3]thiadiazole benzylamide derivatives. However, initial evaluation of mouse liver microsome stability indicated that this series of compounds was rapidly degraded. A structure-activity relationship (SAR) study of the [1,2,3]thiadiazole benzylamide series revealed that increased mouse liver microsome stability and increased necroptosis inhibitory activity could be accomplished by replacement of the 4-cyclopropyl-[1,2,3]thiadiazole with a 5-cyano-1-methylpyrrole. In addition, the SAR and the cellular activity profiles, utilizing different cell types and necroptosis-inducing stimuli, of representative [1,2,3]thiadiazole and pyrrole derivatives were very similar suggesting that the two compound series inhibit necroptosis in the same manner.

Asymmetric rhodium carbene insertion into the Si-H bond: Identification of new dirhodium(II) carboxylate catalysts using parallel synthesis techniques

Decomposition of methyl 2-diazophenylacetate in the presence of silanes and a chiral dirhodium(II) catalyst results in Si-H insertion of the intermediate carbenoid with varying degrees of enantioselectivity. New chiral dirhodium(II) carboxylate catalysts were identified using solution phase parallel synthesis techniques.

New chiral rhodium(II) carboxylates and their use as catalysts in carbenoid transformations

New chiral dirhodium(II) carboxylates 11-15 have been prepared from the half phthalate esters 6-8 and the pyrroles 9 and 10, and their use as catalysts for the decomposition of diazocarbonyl compounds 16 and 18 investigated.