(R)-1-(1-phenylethyl)-1H-Pyrrole-2-carboxylicacid

Base Information

• Chemical Name: (R)-1-(1-phenylethyl)-1H-Pyrrole-2-carboxylicacid
• CAS No.: 173989-76-9
• Molecular Formula: C13H13NO2
• Molecular Weight: 215.2478
• Mol file: 173989-76-9.mol

Synonyms:(R)-1-(1-phenylethyl)-1H-Pyrrole-2-carboxylicacid; 1-[(1R)-1-Phenylethyl]-1H-pyrrole-2-carboxylic acid; 1H-pyrrole-2-carboxylic acid, 1-[(1R)-1-phenylethyl]-

Chemical Property of (R)-1-(1-phenylethyl)-1H-Pyrrole-2-carboxylicacid

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 373.416°C at 760 mmHg
• Flash Point: 179.636°C
• PSA: 42.23000
• Density: 1.137g/cm³
• LogP: 2.79560
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

(R)-1-(1-Phenylethyl)-1H-pyrrole-2-carboxylicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-1-(1-phenylethyl)-1H-Pyrrole-2-carboxylicacid

There total 6 articles about (R)-1-(1-phenylethyl)-1H-Pyrrole-2-carboxylicacid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

(S)-1-(1-phenylethyl)-2-trifluoroacetylpyrrole (571147-98-3) → (S)-1-(1-phenylethyl)pyrrole-2-carboxylic acid (173989-76-9)

Guidance literature:

With lithium hydroxide; In N,N-dimethyl-formamide; at 70 ℃;

DOI:10.1016/S0957-4166(03)00035-1

Reference yield:

C14H15NO2 (1100569-50-3) → C13H13NO2 (1155519-30-4,173989-76-9)

Guidance literature:

With methanol; potassium hydroxide; water; at 20 ℃; for 8h;

DOI:10.1016/j.bmcl.2008.04.048

Reference yield:

(S)-1-(1-phenylethyl)-1H-pyrrole (13245-05-1) → (S)-1-(1-phenylethyl)pyrrole-2-carboxylic acid (173989-76-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / tetrahydrofuran / 2 h / 0 °C

2: 68 percent / lithium hydroxide / dimethylformamide / 70 °C

With lithium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/S0957-4166(03)00035-1

upstream raw materials:

cis,trans-2,5-dimethoxytetrahydrofuran

(R)-1-phenyl-ethyl-amine

trifluoroacetic anhydride

(S)-1-phenyl-ethylamine

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