Design, synthesis, and anti-HCV activity of thiourea compounds
A series of thiourea derivatives were synthesized and their antiviral activity was evaluated in a cell-based HCV subgenomic replicon assay. SAR studies revealed that the chain length and the position of the alkyl linker largely influenced the in vitro anti-HCV activity of this class of potent antiviral agents. Among this series of compounds synthesized, the thiourea derivative with a six-carbon alkyl linker at the meta-position of the central phenyl ring (10) was identified as the most potent anti-HCV inhibitor (EC50 = 0.047 μM) with a selectivity index of 596.
Method for preparing substituted meta-phenylalkoxynitrobenzenes
Methods for the preparation of substituted meta-phenylalkoxynitrobenzenes and their use as starting materials for the synthesis of herbicidal meta-phenylalkoxyphenylurea.
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(2008/06/13)
Irreversible enzyme inhibitors. LXXXVII. Hydrophobic bonding to dihydrofolic reductase. IX. Mode of binding of m-aryloxyalkyl groups on 4,6-diamino-1,2-dihdro-2,2-dimethyl-1-phenyl-s-triazine.
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Baker,Lourens
p. 871 - 875
(2007/10/05)
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