Synthesis of conformationally tailored pentaazacyclopentadeeanes. Preorganizing peptide cyclizations.
A general method for the preparation of rigidified pentaazamacrocycles using trans-(1R,2R)-diaminocyclohexane as the conformational controller element. High macrocyclization yields have been obtained by strategic placement of the diamino-cyclohexane group within the pseudopeptide backbone.
Neumann, William L.,Franklin, Gary W.,Sample, Kirby R.,Aston, Karl W.,Weiss, Randy H.,Riley, Dennis P.