17432-95-0

Basic information

• Product Name: 5-isopropyluracil
• Synonyms: 5-Isopropyluracil; NSC 149002; 2,4(1H,3H)-Pyrimidinedione, 5-(1-methylethyl)-; 5-(propan-2-yl)pyrimidine-2,4(1H,3H)-dione
• CAS NO: 17432-95-0
• Molecular Formula: C₇H₁₀N₂O₂
• Molecular Weight: 154.1665
• Mol File: 17432-95-0.mol

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.142g/cm³
• Refractive Index: 1.487
• CAS DataBase Reference: 5-isopropyluracil(CAS DataBase Reference)
• NIST Chemistry Reference: 5-isopropyluracil(17432-95-0)
• EPA Substance Registry System: 5-isopropyluracil(17432-95-0)

Safety Data

• Hazardous Substances Data: 17432-95-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C7H10N2O2/c1-4(2)5-3-8-7(11)9-6(5)10/h3-4H,1-2H3,(H2,8,9,10,11)

Upstream product

• 108-64-5 Ethyl isovalerate 
• 109-94-4 formic acid ethyl ester 
• 556-24-1 methyl 3-methylbutanoate 
• 96796-80-4 5-isopropyl-6-chloro-2,4-pyrimidinedione 
• 18718-34-8 5-isopropyl-2-thiouracil 
• 7391-69-7 5-isopropylbarbituric acid 

Downstream Products

• 1352571-48-2 2-(3-isopropoxy-5-(4-(methylsulfonyl)phenoxy)phenyl)-5-isopropyl-4-(4-methoxybenzyloxy)pyrimidine 
• 1352570-43-4 2-(3-isopropoxy-5-(4-(methylsulfonyl)phenoxy)phenyl)-5-isopropylpyrimidin-4(3H)-one 
• 1352571-33-5 2-chloro-5-isopropyl-4-(4-methoxybenzyloxy)pyrimidine 
• 99097-07-1 1-(3-O-acetyl-5-O-benzoyl-2-deoxy-2-fluoro-D-arabinofuranosyl)-5-isopropyluracil 
• 76549-87-6 2'-deoxy-3',5'-di-O-(p-tolyl)-α-D-ribofuranoside of 5-i-propyluracil 
• 76540-23-3 2'-deoxy-3',5'-di-O-(p-tolyl)-β-D-ribofuranoside of 5-i-propyluracil 
• 60136-25-6 2'-deoxy-β-D-ribofuranoside of 5-i-propyluracil 
• 175470-85-6 1-((2R,4S,5R)-4-Benzyloxy-5-benzyloxymethyl-tetrahydro-thiophen-2-yl)-5-isopropyl-1H-pyrimidine-2,4-dione 
• 1026863-23-9 1-[2-(tert-Butyl-dimethyl-silanyloxy)-ethoxymethyl]-6-(3,5-dimethyl-phenylselanyl)-5-isopropyl-1H-pyrimidine-2,4-dione 
• 1026694-92-7 1-[2-(tert-Butyl-dimethyl-silanyloxy)-ethoxymethyl]-5-isopropyl-6-m-tolylselanyl-1H-pyrimidine-2,4-dione 
• 1026536-28-6 1-[2-(tert-Butyl-dimethyl-silanyloxy)-ethoxymethyl]-5-isopropyl-6-phenylselanyl-1H-pyrimidine-2,4-dione 
• 172255-88-8 6-[(3,5-dimethylphenyl)selenenyl]-1-[(2-hydroxyethoxy)methyl]-5-isopropyluracil 
• 172255-87-7 1-[(2-hydroxyethoxy)methyl]-5-isopropyl-6-[(3-methylphenyl)-selenenyl]uracil 
• 172255-86-6 1-[(2-hydroxyethoxy)methyl]-5-isopropyl-6-(phenylselenenyl)-uracil 

Relevant articles and documents

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Method for producing 5-isopropyluracil

A method for producing 5-isopropyluracil at a high yield in a short time, wherein N-(2-cyano-3-methylbutanoyl)urea is reduced in a 10-15% aqueous sulfuric acid solution in the presence of palladium carbon at 30-45° C., heated for ring closure reaction and added to a 50-70% aqueous sulfuric acid solution to give 5-isopropyluracil having a high purity.

PYRIMIDINEDIONE, PYRIMIDINETRIONE, TRIAZINEDIONE AND TETRAHYDROQUINAZOLINEDIONE DERIVATIVES AS ALPHA1-ADRENERGIC RECEPTOR ANTAGONISTS

Compounds of Formula I: STR1 where R 5 is a group selected from Formulae (a), (b), (c) and (d): STR2 and the pharmaceutically acceptable salts and N-oxides thereof, are α 1-adrenergic receptor antagonists useful for the treatment of diseases involving directly or indirectly an obstruction of the lower urinary tract, such as benign prostatic hyperplasia.

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