174422-11-8 Usage
Uses
Used in Pharmaceutical Industry:
2-Thiophen-2-yl-1H-benzoimidazole-5-carboxylic acid is used as a key intermediate in the synthesis of pharmaceuticals for its potential role in developing new drugs or therapeutic agents. Its unique structure allows it to be a versatile component in the creation of compounds with targeted biological activities.
Used in Organic Synthesis:
In the field of organic synthesis, 2-thiophen-2-yl-1H-benzoimidazole-5-carboxylic acid serves as a valuable building block for constructing other organic compounds with specific biological properties. Its reactivity and structural features make it suitable for the development of molecules with potential applications in medicine and other related fields.
Used in Drug Development:
2-Thiophen-2-yl-1H-benzoimidazole-5-carboxylic acid is utilized in drug development as a precursor or a structural component in the design of novel pharmaceuticals. Its ability to participate in chemical reactions facilitates the creation of diverse drug candidates with potential therapeutic benefits.
Used in Medicinal Chemistry Research:
In medicinal chemistry research, 2-thiophen-2-yl-1H-benzoimidazole-5-carboxylic acid is employed as a compound of interest for studying its interactions with biological targets. Understanding these interactions can lead to insights that inform the design of more effective drugs and therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 174422-11-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,4,4,2 and 2 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 174422-11:
(8*1)+(7*7)+(6*4)+(5*4)+(4*2)+(3*2)+(2*1)+(1*1)=118
118 % 10 = 8
So 174422-11-8 is a valid CAS Registry Number.
InChI:InChI=1/C12H8N2O2S/c15-12(16)7-3-4-8-9(6-7)14-11(13-8)10-2-1-5-17-10/h1-6H,(H,13,14)(H,15,16)/p-1
174422-11-8Relevant articles and documents
Skin damages—Structure activity relationship of benzimidazole derivatives bearing a 5-membered ring system
Baldisserotto, Anna,Balzarini, Jan,Djuidje, Ernestine Nicaise,Durini, Elisa,Liekens, Sandra,Manfredini, Stefano,Sciabica, Sabrina,Serra, Elena,Vertuani, Silvia
, (2020/10/02)
In the search for scaffolds for multifunctional compounds we investigated the structure activity relationship of a class of benzimidazole derivatives bearing 5-membered ring. The newly synthesized and the already known compounds were divided into three cl
SYNTHESIS OF 1,2-DISUBSTITUTED BENZIMIDAZOLE-5(6)-CARBOXAMIDES AND EVALUATION OF THEIR ANTIMICROBIAL ACTIVITY
Goeker, Hakan,Tebrizli, Emin,Abbasoglu, Ufuk
, p. 53 - 58 (2007/10/03)
A series of 14,N'-(N,N-dialkylaminoethyl)-benzimidazole-5(6) or 5-carboxamides (1-14), having several substituents on the azole and benzene nuclei, were prepared and evalueted in vitro for antimicrobial activity.The precursor bezimidazolecarboxylic acids (15-27) were prepared via oxidative condensation of diaminobenzoic acids and several aldehydes with cupric ion.Compounds 11-14 were prepared by selective regioisomer synthesis.All carboxamides were prepared from the corresponding acids and N,N-dialkylethylenediamine.Antibacterial and antifungal activities were determined as MICs values.Of the synthesized compounds 1-10, 6 and 10 were found to be most favourable.In order to clarify the effect of the substituents at N1 on antimicrobial activity, 12 was prepared by p-chlorobenzyl substitution of compound 6, and increased activity was shown.Compounds 13 and 14, which were prepared by replacement with more bulky alkyl groups on the tert-N atom than 12, gave the best results.
