174561-11-6

Basic information

• Product Name: 1-(4-FLUOROBENZYL)-4-(2-HYDROXYETHYL)PIPERAZINE
• Synonyms: BUTTPARK 46\04-32;2-[4-(4-FLUOROBENZYL)PIPERAZINO]ETHAN-1-OL;1-(4-FLUOROBENZYL)-4-(2-HYDROXYETHYL)PIPERAZINE;1-(4-Fluorobenzyl)-4-(2-hydroxyethyl)piperazine 97%;1-(4-Fluorobenzyl)-4-(2-hydroxyethyl)piperazine97%;2-(4-(4-Fluorobenzyl)piperazin-1-yl)ethanol
• CAS NO: 174561-11-6
• Molecular Formula: C₁₃H₁₉FN₂O
• Molecular Weight: 238.3
• Mol File: 174561-11-6.mol

Chemical Properties

• Melting Point: 55 °C
• Boiling Point: 356 °C at 760 mmHg
• Flash Point: 169.1 °C
• Appearance: /
• Density: 1.155 g/cm³
• Vapor Pressure: 1.1E-05mmHg at 25°C
• Refractive Index: 1.549
• CAS DataBase Reference: 1-(4-FLUOROBENZYL)-4-(2-HYDROXYETHYL)PIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-FLUOROBENZYL)-4-(2-HYDROXYETHYL)PIPERAZINE(174561-11-6)
• EPA Substance Registry System: 1-(4-FLUOROBENZYL)-4-(2-HYDROXYETHYL)PIPERAZINE(174561-11-6)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• Hazardous Substances Data: 174561-11-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-(4-Fluorobenzyl)-4-(2-hydroxyethyl)piperazine is used as a drug candidate for the development of new medications targeting mental health conditions such as depression, anxiety, and schizophrenia. Its unique structural features and potential pharmacological properties make it a promising compound for further research and development in this field.
Used as a Chemical Intermediate:
1-(4-Fluorobenzyl)-4-(2-hydroxyethyl)piperazine is used as a chemical intermediate in the synthesis of other organic compounds, contributing to the advancement of chemical research and the development of new materials and products.

InChI:InChI=1/C13H19FN2O/c14-13-3-1-12(2-4-13)11-16-7-5-15(6-8-16)9-10-17/h1-4,17H,5-11H2

Upstream product

• 103-76-4 1-(2-hydroxyethyl)piperazine 
• 352-11-4 1-chloromethyl-4-fluorobenzene 

Relevant articles and documents

Indazole derivatives having monocyclic amine

An indazole compound having the formula (I): wherein: R1 is hydrogen, C1 -C6 alkyl, C3 -C6 alkenyl or C3 -C6 cycloalkyl; Q is carbonyl, thiocarbonyl or methylene; and R2 is a group of the formula (II) or (IV); STR1 wherein R1 is C1 -C6 alkyl, C3 -C6 alkenyl or benzyl, of which a phenyl group thereof is optionally mono- or di-substituted by the same or different halogen or methoxy; m is 0 to 2; n and o is 1 or 2. The compound exhibits 5-HT4 receptor agonist activity.

Pyrimidine derivatives

Pyrimidine derivatives useful as a gastrointestinal prokinetic agent, represented by formula STR1 wherein X is O or NR5, Y is O, S or NR5 wherein R5 is a hydrogen atom, a C1 -C6 alkyl group or the like; R1 and R2 may be the same or different and each is a hydrogen atom, a C1 -C6 alkyl group or the like; R3 is CN, or COOR6 wherein R6 is a C1 -C6 alkyl group, a C3 -C6 cycloalkyl group, an aryl group or the like; R4 is --SR7 or --NR8 R9 wherein R7 is a C1 -C6 alkyl group; R8 is a C1 -C6 alkyl group or the like; R9 is a hydrogen atom, a C1 -C6 alkyl group or the like, or R8 and R9 may represent, together with the nitrogen atom to which they are attached, an N-substituted piperazine ring of formula (X) STR2 wherein R10 represents a C1 -C6 alkyl group or the like or a pharmacologically acceptable salt thereof. The above-mentioned compounds are useful as a gastrointestinal prokinetic agent used for the therapy of digestive tract diseases.