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1-(2-Hydroxyethyl)piperazine suppliers in China
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USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
Factory Supply Hydroxyethyl Piperazine
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No Data 1 Gram 400 Metric Ton/Day Ality Chemical Corporation Contact Supplier
N-(2-Hydroxyethyl)piperazine
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N-(2-Hydroxyethyl)piperazine
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USD $ 2.0-2.0 / Gram 1 Gram 1000 Metric Ton/Year Jinan Finer Chemical Co., Ltd Contact Supplier
High purity 103-76-4 N-(2-Hydroxyethyl)piperazine
Cas No: 103-76-4
USD $ 100.0-500.0 / Gram 1 Gram 99999 Gram/Year Hangzhou Dingyan Chem Co., Ltd Contact Supplier
High quality Hydroxyethyl Piperazine supplier in China
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No Data No Data Metric Ton/Day Simagchem Corporation Contact Supplier
High purity N-(2-Hydroxyethyl)piperazine CAS 103-76-4 with factory price
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USD $ 12.0-15.0 / Kilogram 200 Kilogram 80 Metric Ton/Month Wuhan Fortuna Chemical Co.,Ltd Contact Supplier
Factory Price API 99% 1-(2-Hydroxyethyl)piperazine 103-76-4 GMP Manufacturer
Cas No: 103-76-4
USD $ 0.1-0.1 / Gram 1 Gram 100 Metric Ton/Year Xi'an Xszo Chem Co., Ltd. Contact Supplier
Amadis Chemical offer CAS#103-76-4;CAT#A1877
Cas No: 103-76-4
No Data 10 Milligram Amadis Chemical Co., Ltd. Contact Supplier

103-76-4 Usage

Chemical Properties

clear colorless to pale yellow oily liquid

Uses

1-(2-Hydroxyethyl)piperazine is a hydroxyalkyl substituted pieprazine used in the preparation of pharmaceutical compounds such as neuroleptic agents.
InChI:InChI=1/C6H14N2O/c1-6(9)8-4-2-7-3-5-8/h6-7,9H,2-5H2,1H3

103-76-4 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Alfa Aesar (A17215)  1-(2-Hydroxyethyl)piperazine, 98+%    103-76-4 10g 224.0CNY Detail
Alfa Aesar (A17215)  1-(2-Hydroxyethyl)piperazine, 98+%    103-76-4 100g 303.0CNY Detail
Alfa Aesar (A17215)  1-(2-Hydroxyethyl)piperazine, 98+%    103-76-4 500g 1255.0CNY Detail
Vetec (V900535)  1-(2-Hydroxyethyl)piperazine  Vetec reagent grade, 98% 103-76-4 V900535-100G 196.56CNY Detail
Aldrich (H28807)  1-(2-Hydroxyethyl)piperazine  98% 103-76-4 H28807-100G 370.89CNY Detail
Aldrich (H28807)  1-(2-Hydroxyethyl)piperazine  98% 103-76-4 H28807-500G 1,552.59CNY Detail

103-76-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name N-(2-Hydroxyethyl)piperazine

1.2 Other means of identification

Product number -
Other names 1-(2-Hydroxyethyl)piperazine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Adhesives and sealant chemicals,Functional fluids (closed systems)
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:103-76-4 SDS

103-76-4Synthetic route

4-[(3-methyl-2-butenyl)oxycarbonyl]-1-(2-hydroxyethyl)piperazine
161742-25-2

4-[(3-methyl-2-butenyl)oxycarbonyl]-1-(2-hydroxyethyl)piperazine

1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

Conditions
ConditionsYield
With diethylamine; Pd(0) (in situ from Pd(OAc)2 and m.sulfonated triphenylphosphine) In water; acetonitrile for 0.25h; 5 molpercent catalyst;100%
2-(4-allyl-piperazin-1-yl)-ethanol
27612-67-5

2-(4-allyl-piperazin-1-yl)-ethanol

1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

Conditions
ConditionsYield
With Thiosalicylic acid; 1,4-di(diphenylphosphino)-butane; bis(dibenzylideneacetone)-palladium(0) In tetrahydrofuran at 20℃; for 0.5h;100%
oxirane
75-21-8

oxirane

piperazine
110-85-0

piperazine

1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

Conditions
ConditionsYield
In various solvent(s) at 40℃; for 0.5h;95%
In water at 15 - 35℃; for 2h; Temperature;81.7%
ethanolamine
141-43-5

ethanolamine

N,N-bis(chloro-2-ethyl)amine
334-22-5

N,N-bis(chloro-2-ethyl)amine

1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

Conditions
ConditionsYield
With potassium carbonate In water at 83℃; for 5h; Temperature;94%
piperazine
110-85-0

piperazine

Glycolaldehyde
141-46-8

Glycolaldehyde

1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

Conditions
ConditionsYield
With manganese; chromium; hydrogen; nickel; aluminium In water at 150℃; under 22502.3 Torr; Temperature; Pressure; Reagent/catalyst; Solvent; Autoclave;92.3%
4-(2-hydroxyethyl)-2-piperazinone
23936-04-1

4-(2-hydroxyethyl)-2-piperazinone

1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

Conditions
ConditionsYield
With ammonia at 40℃; under 1500.15 Torr; for 2.5h;88%
piperazine
110-85-0

piperazine

2-bromoethanol
540-51-2

2-bromoethanol

A

1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

B

1,4-bis(2-hydroxyethyl)piperazine
122-96-3

1,4-bis(2-hydroxyethyl)piperazine

Conditions
ConditionsYield
With hydrogenchloride In methanol; water for 2.5h; pH=8.5; pH-value; Reagent/catalyst; Inert atmosphere;A 86.2%
B n/a
8-methyl-2-(2-n-propoxyphenyl)quinazolin-4(3H)-one
150479-63-3

8-methyl-2-(2-n-propoxyphenyl)quinazolin-4(3H)-one

A

1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

B

2-{5-[4-(2-hydroxyethyl)-1-piperazinylsulphonyl]-2-n-propoxyphenyl}-8-methylquinazolin-4(3H)-one

2-{5-[4-(2-hydroxyethyl)-1-piperazinylsulphonyl]-2-n-propoxyphenyl}-8-methylquinazolin-4(3H)-one

Conditions
ConditionsYield
A n/a
B 84%
2-[2-(ethyloxy)phenyl]quinazoline-4(3H)-one
64055-53-4

2-[2-(ethyloxy)phenyl]quinazoline-4(3H)-one

A

1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

B

2-{2-Ethoxy-5-[4-(2-hydroxyethyl)-1-piperazinyl-sulphonyl]phenyl}quinazolin-4(3H)-one
150479-46-2

2-{2-Ethoxy-5-[4-(2-hydroxyethyl)-1-piperazinyl-sulphonyl]phenyl}quinazolin-4(3H)-one

Conditions
ConditionsYield
A n/a
B 78%
2-[2-(ethyloxy)phenyl]quinazoline-4(3H)-one
64055-53-4

2-[2-(ethyloxy)phenyl]quinazoline-4(3H)-one

A

1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

B

2-{2-Ethoxy-5-[4-(2-hydroxyethyl)-1-piperazinylsulphonyl]phenyl}quinazolin-4(3)-one
150479-46-2

2-{2-Ethoxy-5-[4-(2-hydroxyethyl)-1-piperazinylsulphonyl]phenyl}quinazolin-4(3)-one

Conditions
ConditionsYield
A n/a
B 78%
ethanolamine
141-43-5

ethanolamine

A

1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

B

1,4-bis(2-hydroxyethyl)piperazine
122-96-3

1,4-bis(2-hydroxyethyl)piperazine

Conditions
ConditionsYield
With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; sodium hydrogencarbonate In water at 140℃; for 96h; Inert atmosphere; Heating;A 30%
B 27%
oxirane
75-21-8

oxirane

piperazine
110-85-0

piperazine

A

1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

B

1,4-bis(2-hydroxyethyl)piperazine
122-96-3

1,4-bis(2-hydroxyethyl)piperazine

Conditions
ConditionsYield
With methanol
With methanol
Ethoxy-phenoxy-piperazin-1-yl-methanethiol

Ethoxy-phenoxy-piperazin-1-yl-methanethiol

A

1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

B

O-ethyl O'-phenyl thiocarbonate
116849-48-0

O-ethyl O'-phenyl thiocarbonate

Conditions
ConditionsYield
With potassium chloride In water at 25℃; Rate constant;
N-<β-oxy-ethyl>-piperazine-N'-carboxylic acid ethyl ester

N-<β-oxy-ethyl>-piperazine-N'-carboxylic acid ethyl ester

1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

Conditions
ConditionsYield
With hydrogenchloride
N,N'-bis-<2-hydroxy-ethyl>-ethylenediamine hydrochloride

N,N'-bis-<2-hydroxy-ethyl>-ethylenediamine hydrochloride

A

piperazine
110-85-0

piperazine

B

1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

Conditions
ConditionsYield
at 200℃;
1-(2-bromo-ethyl)-piperazine; dihydrobromide
89727-93-5

1-(2-bromo-ethyl)-piperazine; dihydrobromide

aqueous NaOH

aqueous NaOH

A

1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

B

isomeric compound to 2-piperazino-ethanol C6H14N2O

isomeric compound to 2-piperazino-ethanol C6H14N2O

Conditions
ConditionsYield
at 50℃;
(4-(2-hydroxyethyl)piperazin-1-yl)(phenyl)methanone
56227-56-6

(4-(2-hydroxyethyl)piperazin-1-yl)(phenyl)methanone

1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

Conditions
ConditionsYield
With hydrogenchloride Heating;
2-(3-trifluoromethyl-phenylamino)-nicotinic acid 2-[4-(2-hydroxy-ethyl)-piperazin-1-yl]-2-oxo-ethyl ester

2-(3-trifluoromethyl-phenylamino)-nicotinic acid 2-[4-(2-hydroxy-ethyl)-piperazin-1-yl]-2-oxo-ethyl ester

A

1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

B

2-(3-trifluoromethyl-phenylamino)nicotinic acid carboxymethyl ester

2-(3-trifluoromethyl-phenylamino)nicotinic acid carboxymethyl ester

Conditions
ConditionsYield
With phosphate buffer; potassium chloride In methanol at 37℃; for 8h; pH=7.4; Kinetics; Further Variations:; pH-values;
4-(2-Allyloxycarbonyloxy-ethyl)-piperazine-1-carboxylic acid 3-methyl-but-2-enyl ester

4-(2-Allyloxycarbonyloxy-ethyl)-piperazine-1-carboxylic acid 3-methyl-but-2-enyl ester

1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 100 percent / diethylamine / Pd(0) (in situ from Pd(OAc)2 and m.sulfonated triphenylphosphine) / H2O; various solvent(s) / 0.33 h / 5 molpercent catalyst
2: 100 percent / diethylamine / Pd(0) (in situ from Pd(OAc)2 and m.sulfonated triphenylphosphine) / H2O; acetonitrile / 0.25 h / 5 molpercent catalyst
View Scheme
ethylenediamine
107-15-3

ethylenediamine

A

piperazine
110-85-0

piperazine

B

1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

C

aminoethylpiperazine
140-31-8

aminoethylpiperazine

D

2-(2-Aminoethylamino)ethanol
111-41-1

2-(2-Aminoethylamino)ethanol

E

1,5-diamino-3-azapentane
111-40-0

1,5-diamino-3-azapentane

F

triethylentetramine
112-24-3

triethylentetramine

Conditions
ConditionsYield
With hydrogen at 150 - 160℃; under 22502.3 Torr;
ethanolamine
141-43-5

ethanolamine

A

piperazine
110-85-0

piperazine

B

1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

C

aminoethylpiperazine
140-31-8

aminoethylpiperazine

D

2-(2-Aminoethylamino)ethanol
111-41-1

2-(2-Aminoethylamino)ethanol

E

ethylenediamine
107-15-3

ethylenediamine

F

1,5-diamino-3-azapentane
111-40-0

1,5-diamino-3-azapentane

G

triethylentetramine
112-24-3

triethylentetramine

Conditions
ConditionsYield
With ammonia; hydrogen at 170℃; under 150015 Torr;
piperazine
110-85-0

piperazine

Iodoethanol
624-76-0

Iodoethanol

1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

Conditions
ConditionsYield
With potassium carbonate; sodium iodide In ethanol for 12h; Reflux;
triethanolamine
102-71-6

triethanolamine

A

piperazine
110-85-0

piperazine

B

1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

C

aminoethylpiperazine
140-31-8

aminoethylpiperazine

Conditions
ConditionsYield
With ammonia; hydrogen; Ni/Re (6.8wtpercent/1.8wtpercent) on silica/alumina (80/20) at 170℃; under 85781.4 - 99537.9 Torr; for 16h; Product distribution / selectivity; Autoclave;
triethanolamine
102-71-6

triethanolamine

A

piperazine
110-85-0

piperazine

B

1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

C

aminoethylpiperazine
140-31-8

aminoethylpiperazine

D

N,N-bis(2-hydroxyethyl)ethylidenediamine
3197-06-6

N,N-bis(2-hydroxyethyl)ethylidenediamine

Conditions
ConditionsYield
With ammonia; hydrogen; Ni/Re (6.8wtpercent/1.8wtpercent) on silica/alumina (80/20) at 170℃; under 85781.4 - 99537.9 Torr; for 10h; Product distribution / selectivity; Autoclave;
1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

tert-butyl 4-(2-hydroxyethyl)piperazine-1-carboxylate
77279-24-4

tert-butyl 4-(2-hydroxyethyl)piperazine-1-carboxylate

Conditions
ConditionsYield
In tetrahydrofuran for 3h;100%
With triethylamine In tetrahydrofuran100%
In tetrahydrofuran for 2h;100%
1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

4-chlorobutyric acid 3-diethylaminopropyl ester
845526-60-5

4-chlorobutyric acid 3-diethylaminopropyl ester

4-[4-(2-hydroxyethyl)piperazin-1-yl]butyric acid 3-diethylaminopropyl ester
845526-69-4

4-[4-(2-hydroxyethyl)piperazin-1-yl]butyric acid 3-diethylaminopropyl ester

Conditions
ConditionsYield
With potassium carbonate In toluene at 100℃; for 48h;100%
1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

4-fluoro-2-nitrobenzaldehyde
2923-96-8

4-fluoro-2-nitrobenzaldehyde

4-[4-(2-hydroxyethyl)piperazin-1-yl]-2-nitrobenzaldehyde
904896-09-9

4-[4-(2-hydroxyethyl)piperazin-1-yl]-2-nitrobenzaldehyde

Conditions
ConditionsYield
In dimethyl sulfoxide at 100℃; for 1.5h;100%
1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

benzyl chloroformate
501-53-1

benzyl chloroformate

benzyl 4-(2-hydroxyethyl)-1-piperazinecarboxylate
14000-67-0

benzyl 4-(2-hydroxyethyl)-1-piperazinecarboxylate

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 0 - 20℃; for 3.5h;100%
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 24h;91%
With sodium hydroxide In water; acetonitrile at 20℃; pH=9; Inert atmosphere;90%
1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

2,4-dichloro-2-methylpyrimidine
1780-26-3

2,4-dichloro-2-methylpyrimidine

2-(4-(6-chloro-2-methylpyrimidin-4-yl)piperazin-1-yl)ethanol
127116-19-2

2-(4-(6-chloro-2-methylpyrimidin-4-yl)piperazin-1-yl)ethanol

Conditions
ConditionsYield
With triethylamine In dichloromethane at 30℃;100%
Stage #1: 1-(2-hydroxyethyl)piperazine; 2,4-dichloro-2-methylpyrimidine In dichloromethane at 30℃; for 2.5h;
Stage #2: With triethylamine In dichloromethane
89.8%
Stage #1: 1-(2-hydroxyethyl)piperazine; 2,4-dichloro-2-methylpyrimidine In dichloromethane at 30℃; for 2.5h;
Stage #2: With triethylamine In dichloromethane
89.8%
1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

(2′Z-3′E)-6-bromoindirubin-3′-[O-(2-bromoethyl)oxime]
1067884-35-8

(2′Z-3′E)-6-bromoindirubin-3′-[O-(2-bromoethyl)oxime]

(2'Z-3'E)-6-bromoindirubin-3'-(O-{2-[4-(2-hydroxyethyl)piperazin-1-yl]ethyl}oxime)
1067884-47-2

(2'Z-3'E)-6-bromoindirubin-3'-(O-{2-[4-(2-hydroxyethyl)piperazin-1-yl]ethyl}oxime)

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 50℃;100%
In N,N-dimethyl-formamide at 90℃; for 0.666667h; Inert atmosphere; Microwave irradiation;
1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

methyl 2-cyanoacetate
105-34-0

methyl 2-cyanoacetate

3-[4-(2-hydroxyethyl)piperazin-1-yl]-3-oxopropanenitrile
15029-35-3

3-[4-(2-hydroxyethyl)piperazin-1-yl]-3-oxopropanenitrile

Conditions
ConditionsYield
neat (no solvent);100%
1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

5,7-dichloro-2-phenylpyrazolo[1,5-a]pyrimidine
1159982-72-5

5,7-dichloro-2-phenylpyrazolo[1,5-a]pyrimidine

5-Chloro-7-[1-(2-hydroxyethyl)-piperazin-4-yl]-2-phenyl-pyrazolo[1,5-a]-pyrimidine
1232224-20-2

5-Chloro-7-[1-(2-hydroxyethyl)-piperazin-4-yl]-2-phenyl-pyrazolo[1,5-a]-pyrimidine

Conditions
ConditionsYield
In 1,4-dioxane at 1 - 30℃; for 1h;100%
1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

cis-10-(3-Dimethylamino-propyliden)-2-trifluormethyl-thiaxanthen
95365-88-1

cis-10-(3-Dimethylamino-propyliden)-2-trifluormethyl-thiaxanthen

2-{4-[3-(2-trifluoromethyl-thioxanthen-9-ylidene)-propyl]-piperazin-1-yl}-ethanol
2709-56-0

2-{4-[3-(2-trifluoromethyl-thioxanthen-9-ylidene)-propyl]-piperazin-1-yl}-ethanol

Conditions
ConditionsYield
at 140℃; for 36h; Temperature; Large scale;100%
1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

N-[2,4-dibromo-6-methylpyridin-3-yl]-2-bromoacetamide

N-[2,4-dibromo-6-methylpyridin-3-yl]-2-bromoacetamide

N-[2,4-dibromo-6-methylpyridin-3-yl]-2-[4-(2-hydroxyethyl)piperazin-1-yl]acetamide

N-[2,4-dibromo-6-methylpyridin-3-yl]-2-[4-(2-hydroxyethyl)piperazin-1-yl]acetamide

Conditions
ConditionsYield
With potassium carbonate In acetonitrile at 20℃; for 24h;99%
1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

6-chloro-N-methyl-4-propylnicotinamide
1254043-23-6

6-chloro-N-methyl-4-propylnicotinamide

6-[4-(2-hydroxyethyl)piperazin-1-yl]-N-methyl-4-propylnicotinamide
1254043-24-7

6-[4-(2-hydroxyethyl)piperazin-1-yl]-N-methyl-4-propylnicotinamide

Conditions
ConditionsYield
In tetrahydrofuran at 20 - 100℃; for 18h;99%
1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

3,4-bis(phenylsulfonyl)-1,2,5-oxadiazole 2-oxide
66074-00-8

3,4-bis(phenylsulfonyl)-1,2,5-oxadiazole 2-oxide

3-(phenylsulfonyl)-4-(2-(piperazin-1-yl)ethoxy)-1,2,5-oxadiazole-2-oxide
1245575-37-4

3-(phenylsulfonyl)-4-(2-(piperazin-1-yl)ethoxy)-1,2,5-oxadiazole-2-oxide

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran at 0℃; for 4h;99%
With sodium hydride In tetrahydrofuran at 0℃; for 4h;99%
With sodium hydroxide In tetrahydrofuran; water at 0 - 20℃;56%
1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

4,6-diiodo-2-methylpyrimidine
66298-49-5

4,6-diiodo-2-methylpyrimidine

2-(4-(6-iodo-2-methylpyrimidin-4-yl)piperazin-1-yl)ethanol

2-(4-(6-iodo-2-methylpyrimidin-4-yl)piperazin-1-yl)ethanol

Conditions
ConditionsYield
With triethylamine In isopropyl alcohol at 60℃; for 1h;99%
1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

3,3'-bis(3-bromopropoxy)-2,2'-dimethyl-1,1'-biphenyl

3,3'-bis(3-bromopropoxy)-2,2'-dimethyl-1,1'-biphenyl

trifluoroacetic acid
76-05-1

trifluoroacetic acid

2,2'-((((2,2'-dimethyl-[1,1'-biphenyl]-3,3'-diyl)bis(oxy))bis(propane-3,1-diyl))bis(piperazine-4,1-diyl))bis(ethan-1-ol) trifluoroacetate

2,2'-((((2,2'-dimethyl-[1,1'-biphenyl]-3,3'-diyl)bis(oxy))bis(propane-3,1-diyl))bis(piperazine-4,1-diyl))bis(ethan-1-ol) trifluoroacetate

Conditions
ConditionsYield
Stage #1: 1-(2-hydroxyethyl)piperazine; 3,3'-bis(3-bromopropoxy)-2,2'-dimethyl-1,1'-biphenyl With N-ethyl-N,N-diisopropylamine In methanol at 65℃; for 72h; Inert atmosphere;
Stage #2: trifluoroacetic acid In water; acetonitrile
99%
1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

1'-(2-bromoacetyl)spiro[chromane-2,4'-piperidin]-4-one

1'-(2-bromoacetyl)spiro[chromane-2,4'-piperidin]-4-one

1'-(2-(4-(2-hydroxyethyl)piperazin-1-yl)acetyl)spiro[chromane-2,4'-piperidin]-4-one

1'-(2-(4-(2-hydroxyethyl)piperazin-1-yl)acetyl)spiro[chromane-2,4'-piperidin]-4-one

Conditions
ConditionsYield
With potassium carbonate; sodium iodide In N,N-dimethyl-formamide at 60℃; for 2h;99%
1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

2-(chloromethyl)-1-(ethoxyethyl)-1H-benzimidazole
95893-90-6

2-(chloromethyl)-1-(ethoxyethyl)-1H-benzimidazole

2-{4-[1-(2-Ethoxy-ethyl)-1H-benzoimidazol-2-ylmethyl]-piperazin-1-yl}-ethanol
95894-06-7

2-{4-[1-(2-Ethoxy-ethyl)-1H-benzoimidazol-2-ylmethyl]-piperazin-1-yl}-ethanol

Conditions
ConditionsYield
In 1,4-dioxane at 50℃; for 2h;98%
1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

ethyl 2,3-dihydro-1,4-benzodioxin-2-carboxylate
4739-94-0

ethyl 2,3-dihydro-1,4-benzodioxin-2-carboxylate

N-(2,3-dihydrobenzo<1,4>dioxin-2-carbonyl)-N'-(2-hydroxyethyl)piperazine

N-(2,3-dihydrobenzo<1,4>dioxin-2-carbonyl)-N'-(2-hydroxyethyl)piperazine

Conditions
ConditionsYield
at 110℃; for 3h;98%
1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

methyl 6,11-dioxo-6,11- dihydrobenzo[f]pyrido [1,2-a]indole-12-carboxylate
98596-13-5

methyl 6,11-dioxo-6,11- dihydrobenzo[f]pyrido [1,2-a]indole-12-carboxylate

12-[4-(2-hydroxy-ethyl)-piperazine-1-carbonyl]-benzo[f]pyrido[1,2-a]indole-6,11-dione

12-[4-(2-hydroxy-ethyl)-piperazine-1-carbonyl]-benzo[f]pyrido[1,2-a]indole-6,11-dione

Conditions
ConditionsYield
at 80℃; for 3h;98%
1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

methyl 7,10-dihydroxy-6,11-dioxo-6,11-dihydro-benzo[f]pyrido[1,2-a]indole-12-carboxylate
937394-83-7

methyl 7,10-dihydroxy-6,11-dioxo-6,11-dihydro-benzo[f]pyrido[1,2-a]indole-12-carboxylate

7,10-dihydroxy-12-[4-(2-hydroxy-ethyl)-piperazine-1-carbonyl]-benzo[f]pyrido[1,2-a]indole-6,11-dione

7,10-dihydroxy-12-[4-(2-hydroxy-ethyl)-piperazine-1-carbonyl]-benzo[f]pyrido[1,2-a]indole-6,11-dione

Conditions
ConditionsYield
at 80℃; for 3h;98%
1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

C16H20BrF3O4

C16H20BrF3O4

C22H33F3N2O5

C22H33F3N2O5

Conditions
ConditionsYield
In tetrahydrofuran at 0 - 20℃; for 5h;98%
1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

4-fluorobenzaldehyde
459-57-4

4-fluorobenzaldehyde

4-benzaldehyde

4-benzaldehyde

Conditions
ConditionsYield
With potassium carbonate In water at 100℃; for 12h;98%
With potassium carbonate In water at 80℃; for 24h;95%
With potassium carbonate In dimethyl sulfoxide at 100℃; for 12h;70%
1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

2,4-dichloro-2-methylpyrimidine
1780-26-3

2,4-dichloro-2-methylpyrimidine

2-amino-7-hydroxy-4-(4-methoxyphenyl)-1,4-dihydroquinoline-3-carbonitrile

2-amino-7-hydroxy-4-(4-methoxyphenyl)-1,4-dihydroquinoline-3-carbonitrile

2-amino-7-((6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)oxy)-4-(4-methoxyphenyl)-1,4-dihydroquinoline-3-carbonitrile

2-amino-7-((6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)oxy)-4-(4-methoxyphenyl)-1,4-dihydroquinoline-3-carbonitrile

Conditions
ConditionsYield
Stage #1: 2-amino-7-hydroxy-4-(4-methoxyphenyl)-1,4-dihydroquinoline-3-carbonitrile With potassium carbonate In acetone at 20℃; for 0.25h;
Stage #2: 2,4-dichloro-2-methylpyrimidine In acetone at 80℃; for 0.25h;
Stage #3: 1-(2-hydroxyethyl)piperazine In acetone at 80℃; for 12h;
98%
1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

2-(chloromethyl)-6-nitro-1H-benzo[d]imidazole
14625-39-9

2-(chloromethyl)-6-nitro-1H-benzo[d]imidazole

2-(4-((6-nitro-1H-benzo[d]imidazol-2-yl)methyl)piperazin-1-yl)ethan-1-ol

2-(4-((6-nitro-1H-benzo[d]imidazol-2-yl)methyl)piperazin-1-yl)ethan-1-ol

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 3h;97.8%
With potassium carbonate In tetrahydrofuran at 20℃; for 1h;87.6%
1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

2-Thiophenecarbonyl chloride
5271-67-0

2-Thiophenecarbonyl chloride

Thiophene-2-carboxylic acid 2-[4-(thiophene-2-carbonyl)-piperazin-1-yl]-ethyl ester
80838-51-3

Thiophene-2-carboxylic acid 2-[4-(thiophene-2-carbonyl)-piperazin-1-yl]-ethyl ester

Conditions
ConditionsYield
In benzene for 1h; Heating;97%
1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

2,6-bis(3-chloropropionamido)anthracene-9,10-dione
72966-79-1

2,6-bis(3-chloropropionamido)anthracene-9,10-dione

2,6-bis<3-<4-(2-hydroxyethyl)piperazino>propionamido>anthracene-9,10-dione
134888-47-4

2,6-bis<3-<4-(2-hydroxyethyl)piperazino>propionamido>anthracene-9,10-dione

Conditions
ConditionsYield
In ethanol for 14h; Heating;97%
1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

2-chloro-4-(4-fluorophenyl)quinoline
105189-21-7

2-chloro-4-(4-fluorophenyl)quinoline

2-[4-(2-hydroxyethyl)-1-piperazinyl]-4-(4-fluorophenyl)quinoline dihydrochloride
105188-98-5

2-[4-(2-hydroxyethyl)-1-piperazinyl]-4-(4-fluorophenyl)quinoline dihydrochloride

Conditions
ConditionsYield
at 130℃; for 2h;97%
In water
1-thiaspiro<2.5>octane
185-78-4

1-thiaspiro<2.5>octane

1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

2-[4-(1-mercapto-cyclohexylmethyl)-piperazin-1-yl]-ethanol

2-[4-(1-mercapto-cyclohexylmethyl)-piperazin-1-yl]-ethanol

Conditions
ConditionsYield
at 80℃; for 4h;97%
1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
302964-08-5

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

dasatanib
302962-49-8

dasatanib

Conditions
ConditionsYield
With tetrabutylammomium bromide In acetonitrile at 30 - 80℃;97%
In propan-1-ol at 115 - 120℃; Temperature;93%
With copper(l) chloride In N,N-dimethyl-formamide at 65℃; for 2h; Temperature; Reagent/catalyst;91.6%

103-76-4Upstream product

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