103-76-4Relevant articles and documents
Selective deprotective method using palladium-water soluble catalysts
Lemaire-Audoire,Lemaire-Audoire, Sandrine,Savignac,Savignac, Monique,Blart,Blart, Errol,Pourcelot,Pourcelot, Guy,Genet,Genet, Jean Pierre,Bernard,Bernard, Jean-Marie
, p. 8783 - 8786 (1994)
Allylcarboxy and Allyloxycarbonyl groups can be removed without affecting dimethylallylcarboxy and cinnamylcarboxy groups in the same molecule. using Pd(O) water soluble catalyst prepared in situ, with diethylamine as allyl scavenger. Homogeneous or biphasic media are suitable: the yields of deprotection are quantitative.
Synthesis method of N-hydroxyethylpiperazine
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Paragraph 0027-0078, (2020/06/20)
The invention discloses a synthesis method of N-hydroxyethylpiperazine, which comprises the following steps: by using piperazine and hydroxyacetaldehyde as raw materials and carrying out intermolecular dehydration condensation with hydrogen in the presence of a catalyst to generate N-hydroxyethylpiperazine; wherein the catalyst is composed of a Raney skeleton element and other auxiliary elements (at least one of iron, manganese, zinc, chromium, zirconium and cobalt) loaded on the Raney skeleton element. The method is simple in process operation, high in conversion rate, good in selectivity, simple in post-treatment and environment-friendly. Some examples prove that the yield of the method can reach about 90%, so that the method has a good industrial prospect.
Biocatalytic Access to Piperazines from Diamines and Dicarbonyls
Borlinghaus, Niels,Gergel, Sebastian,Nestl, Bettina M.
, p. 3727 - 3732 (2018/04/14)
Given the widespread importance of piperazines as building blocks for the production of pharmaceuticals, an efficient and selective synthesis is highly desirable. Here we show the direct synthesis of piperazines from 1,2-dicarbonyl and 1,2-diamine substrates using the R-selective imine reductase from Myxococcus stipitatus as biocatalyst. Various N- and C-substituted piperazines with high activity and excellent enantioselectivity were obtained under mild reaction conditions reaching up to 8.1 g per liter.