cas 175136-20-6, 4-(3,4-DICHLOROBENZYLOXY)-3-NITROBENZALDEHYDE | Articles data ｜lookchem

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175136-20-6

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Optimization of 3-aryl-3-ethoxypropanoic acids and discovery of the potent GPR40 agonist DS-1558
GPR40 agonists stimulate insulin secretion only under the presence of high glucose concentration. Based on this mechanism, GPR40 agonists are believed to be promising novel insulin secretagogues with low risk of hypoglycemia. The optimizations of 3-aryl-3-ethoxypropanoic acids were performed to improve in vitro activity. We discovered compound 29r (DS-1558), (3S)-3-ethoxy-3-(4-{[(1R)-4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)propanoic acid, which was confirmed to have an enhancing effect on glucose-dependent insulin secretion after intravenous glucose injection in SD rats.
Takano, Rieko,Yoshida, Masao,Inoue, Masahiro,Honda, Takeshi,Nakashima, Ryutaro,Matsumoto, Koji,Yano, Tatsuya,Ogata, Tsuneaki,Watanabe, Nobuaki,Hirouchi, Masakazu,Kimura, Takako,Toda, Narihiro
p. 5546 - 5565
(2015/11/11)

CARBOXYLIC ACID COMPOUND
To find a therapeutic agent and/or a preventive agent for diabetes mellitus or the like having excellent activity and safety. A compound represented by the following general formula (I), or a pharmacologically acceptable salt thereof. In the formula, X re
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Page/Page column 48

(2011/04/14)

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Chemical Properties

Boiling Point: 493.3 °C at 760 mmHg
Flash Point:252.1 °C
Density: 1.472g/cm³
Vapor Pressure: 7.14E-10mmHg at 25°C
Refractive Index: 1.646
PSA: 72.12000
LogP: 4.81630

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