175205-14-8 Usage
Uses
Used in Organic Synthesis:
5-BROMO-2-METHOXY-OMEGA-NITROSTYRENE is used as a key intermediate in organic synthesis for the creation of various chemical compounds. Its unique structure allows for versatile reactions and modifications, contributing to the synthesis of a wide range of organic molecules.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 5-BROMO-2-METHOXY-OMEGA-NITROSTYRENE is used as a research compound for the development of new drugs. Its properties make it suitable for exploring its potential therapeutic effects and mechanisms of action, which could lead to the discovery of novel pharmaceutical agents.
Used in Agrochemical Development:
5-BROMO-2-METHOXY-OMEGA-NITROSTYRENE is also utilized in the agrochemical sector for the development of new pesticides and other agricultural chemicals. Its chemical structure offers potential applications in enhancing crop protection and productivity.
Safety Precautions:
Given the potential hazards associated with 5-BROMO-2-METHOXY-OMEGA-NITROSTYRENE, it is essential to handle this chemical with caution. Proper safety measures should be implemented to prevent ingestion, inhalation, or skin contact. Additionally, it should be stored and disposed of according to established safety regulations to minimize risks to human health and the environment.
Check Digit Verification of cas no
The CAS Registry Mumber 175205-14-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,5,2,0 and 5 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 175205-14:
(8*1)+(7*7)+(6*5)+(5*2)+(4*0)+(3*5)+(2*1)+(1*4)=118
118 % 10 = 8
So 175205-14-8 is a valid CAS Registry Number.
InChI:InChI=1/C9H8BrNO3/c1-14-9-3-2-8(10)6-7(9)4-5-11(12)13/h2-6H,1H3/b5-4+
175205-14-8Relevant articles and documents
1-[2-methoxy-5-(3-phenylpropyl)]-2-aminopropane unexpectedly shows 5-HT2A serotonin receptor affinity and antagonist character
Rangisetty,Dukat,Dowd,Herrick-Davis,DuPre,Gadepalli,Teitler,Kelley,Sharif,Glennon
, p. 3283 - 3291 (2007/10/03)
Certain phenylethylamines, such as 1-(4-bromo-2,5-dimethoxyphenyl)-2-aminopropane (DOB; 1a), are high-affinity 5-HT2 agonists. Previous structure - affinity studies have concluded that both the 2,5-dimethoxy substitution pattern and the nature of substituents at the 4-position are important determinants of high affinity. We recently demonstrated that replacement of the bromo group of DOB with a 3-(phenyl)propyl substituent results in retention of affinity and that, counter to established structure - affinity relationships, the 2,5-dimethoxy substitution pattern is no longer a requirement for the binding. The present investigation extends these findings by examining a series of analogues, 3, lacking a 5-methoxy group. It was additionally found that shifting the phenylalkyl substituent from the 4- to the 5-position (e.g., 4i) also results in retention of affinity. For example, 1-(2-methoxy-5-(3-phenylpropyl)-2-aminopropane (6; the α-methyl derivative of 4i) binds at 5-HT2A receptors with high affinity (Ki = 13 nM) and possesses 5-HT2A antagonist character. Thus, not only is the 2,5-dimethoxy substitution pattern not a requirement for the binding of certain phenylethylamines at 5-HT2A receptors, the presence of a 4-position substituent (previously thought to serve as a modulator of affinity of DOB-like agents) is also not required. Striking differences in the 5-HT2A binding requirements of the present compounds as compared to DOB-like agents suggest multiple substituent-dependent modes of binding.
