175210-67-0Relevant articles and documents
Pyridone-based peptidomimetic inhibitors of interleukin-1β-converting enzyme (ICE)
Semple, Graeme,Ashworth, Doreen M.,Baker, Graham R.,Batt, Andrzej R.,Baxter, Andrew J.,Benzies, David W.M.,Elliot, Lucy H.,Evans, D. Michael,Franklin, Richard J.,Hudson, Peter,Jenkins, Paul D.,Pitt, Gary R.,Rooker, David P.,Sheppard, Andrew,Szelke, Michael,Yamamoto, Satoshi,Isomura, Yasuo
, p. 1337 - 1342 (2007/10/03)
New potent, reversible inhibitors of recombinant human Interleukin-1 β-converting enzyme (ICE, caspase-1) with significantly reduced peptide character are described. The compounds were designed by incorporation of pyridone and pyrimidone heterocyclic replacements for the P2-P3 amino acids of the native substrate and were optimised by manipulation of peripheral alkyl and aryl substituents.
Structure-based design of non-peptidic pyridone aldehydes as inhibitors of interleukin-1β converting enzyme.
Golec, Julian M. C.,Mullican, Michael D.,Murcko, Mark A.,Wilson, Keith P.,Kay, David P.,Jones, Stuart D.,Murdoch, Robert,Bemis, Guy W.,Raybuck, Scott A.,Luong, Yu-Ping,Livingston, David J.
, p. 2181 - 2186 (2007/10/03)
Pyridone derivatives, especially with 6-aryl substituents, have been shown to be useful P2-P3 peptidomimetic scaffolds for the design of potent inhibitors of ICE.