175692-06-5

Basic information

• Product Name: BIPHENYL-2-CARBOXAMIDINE
• Synonyms: BIPHENYL-2-CARBOXAMIDINE;Biphenyl-2-carboxamidine HCl;Biphenyl-2-carboxamidine hydrochloride
• CAS NO: 175692-06-5
• Molecular Formula: C₁₃H₁₂N₂
• Molecular Weight: 196.25
• Product Categories: pharmacetical
• Mol File: 175692-06-5.mol

Chemical Properties

• Boiling Point: 386.6°Cat760mmHg
• Flash Point: 187.6°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 2.35E-06mmHg at 25°C
• CAS DataBase Reference: BIPHENYL-2-CARBOXAMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: BIPHENYL-2-CARBOXAMIDINE(175692-06-5)
• EPA Substance Registry System: BIPHENYL-2-CARBOXAMIDINE(175692-06-5)

Safety Data

• Hazardous Substances Data: 175692-06-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C13H12N2.ClH/c14-13(15)12-9-5-4-8-11(12)10-6-2-1-3-7-10;/h1-9H,(H3,14,15);1H

Upstream product

• 98-80-6 phenylboronic acid 
• 2042-37-7 o-cyanobromobenzene 
• 24973-49-7 biphenyl-2-carbonitrile 

Downstream Products

• 908009-82-5 2-(biphenyl-2-yl)-6-(phenylsulfonyl)-5,6,7,8-tetrahydro-3H-quinazolin-4-one 
• 908009-89-2 2-(biphenyl-2-yl)-7,8-dihydro-3H-quinazolin-4-one 
• 908009-75-6 3-(biphenyl-2-yl)-2,4-diazabicylo[4.2.0]octa-1⁽⁶⁾,2-dien-5-one 

Relevant articles and documents

ANTIBACTERIAL AGENT

PROBLEM TO BE SOLVED: To provide an antibacterial agent having antibacterial property on bacteria selected from a group consisting of Methylobacterium bacteria, Sphingomonas bacteria, and Escherichia coil. SOLUTION: There is provided an antibacterial agen

Access to variously substituted 5,6,7,8-tetrahydro-3H-quinazolin-4-ones via Diels-Alder adducts of phenyl vinyl sulfone to cyclobutene-annelated pyrimidinones

Under basic conditions (Et3N, dioxane), the aromatic amidines 4 and also S-methylisothiourea 4g cleanly undergo Michael addition to methyl 2-chloro-2-cyclopropylideneacetate (5), followed by intramolecular nucleophilic substitution, cyclopropyl

TETRAHYDRO- AND DIHYDROQUINAZOLINONES

The present invention relates to the use of tetrahydro- and dihydroquinazolinones of formula (I) as protein kinase activators or inhibitors, a method for their manufacture, their use for the preparation of a medicament for the treatment of diseases, their

Syntheses and selective inhibitory activities of terphenyl-bisamidines for serine proteases

Biphenyl nitriles 5a-c, terphenyl dinitriles 11a-d, and naphthalene-bis(benzonitrile) 11e were prepared by palladium-catalyzed cross coupling reactions and subsequently converted to biphenyl amidines 8a-c and bis(benzamidines) 4a-e. Among the biphenyl amidines 8 only the meta-derivative 8b inhibits factor Xa and trypsin (K(i) = 10 μM). The terphenyl bisamidine 4c does not inhibit factor Xa, trypsin, thrombin, and plasmin, while 4a and 4d are almost equipotent inhibitors of theses enzymes (K(i) 1-6 μM), and 4b and 4e are selective for trypsin (K(i) = 0.2 and 0.3 μM; but K(i) > 1 μM for factor Xa, thrombin, and plasmin). X-ray analysis of crystals of 4b complexed with bovine trypsin revealed a unique binding mode: one benzamidino group binds in the S1 site to the side chain carboxylate of Arg 189. The central phenyl group is twisted away from the S2/S3 sites and the second amidino group contacts the Asn 143 side chain.