176100-76-8

Basic information

• Product Name: 6-HYDROXY-2-(4-NITROPHENYL)-4(3H)-PYRIMIDINONE
• Synonyms: 6-HYDROXY-2-(4-NITROPHENYL)-4(3H)-PYRIMIDINONE
• CAS NO: 176100-76-8
• Molecular Formula: C₁₀H₇N₃O₄
• Molecular Weight: 0
• Mol File: 176100-76-8.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-HYDROXY-2-(4-NITROPHENYL)-4(3H)-PYRIMIDINONE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-HYDROXY-2-(4-NITROPHENYL)-4(3H)-PYRIMIDINONE(176100-76-8)
• EPA Substance Registry System: 6-HYDROXY-2-(4-NITROPHENYL)-4(3H)-PYRIMIDINONE(176100-76-8)

Safety Data

• Hazardous Substances Data: 176100-76-8(Hazardous Substances Data)

Upstream product

• 105-53-3 diethyl malonate 
• 619-72-7 4-nitrobenzonitrile 
• 555-16-8 4-nitrobenzaldehdye 
• 15723-90-7 4-nitrobenzamidine hydrochloride 

Downstream Products

• 83217-23-6 4,6-dichloro-2-(4-nitrophenyl)pyrimidine 
• 83217-40-7 4-(4,6-dichloropyrimidin-2-yl)aniline 

Relevant articles and documents

Design, synthesis and biological evaluation of novel 2-phenyl pyrimidine derivatives as potent Bruton's tyrosine kinase (BTK) inhibitors

BTK is an effective target for the treatment of B-cell malignant tumors and autoimmune diseases. In this work, a series of 2-phenyl pyrimidine derivatives were prepared and their preliminary in vitro activities on B-cell leukemia cells as well as the BTK enzyme were determined. The results showed that compound 11g displayed the best inhibitory activity on BTK with an inhibition rate of 82.76% at 100 nM and excellent anti-proliferation activity on three B-cell leukemia lines (IC50 = 3.66 μM, 6.98 μM, and 5.39 μM against HL60, Raji and Ramos, respectively). Besides, the flow cytometry analysis results indicated that 11g inhibited the proliferation of the Raji cells in a dose- and time-dependent manner, and blocked the Ramos cells at the G0/G1 phase, which is in accordance with the positive control ibrutinib. The mechanism investigation demonstrated that 11g could inhibit the phosphorylation of BTK and its downstream substrate phospholipase γ2 (PLCγ2). All these results showed that 11g was a promising lead compound that merited further optimization as a novel class of BTK inhibitor for the treatment of B-cell lymphoblastic leukemia.

2-phenylpyrimidine compounds, preparation method and medical application

The invention belongs to the field of medicines and particularly relates to 2-phenylpyrimidine compounds and pharmacologically-acceptable salts thereof and an isotope marker. The invention also discloses a pharmaceutical composition containing the substances and application of the pharmaceutical composition for treating diseases related with protein kinase activity, such as cancer and inflammation. (The formula is shown in the description).

PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES

The invention relates to pyrimidine compounds of the Formula I: or a pharmaceutically acceptable salt thereof, wherein the constituent variables are as defined herein, compositions comprising the compounds, and methods for making and using the compounds.