The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of CRBN, and the treatment of CRBN-mediated disorders.
-
Paragraph 00473-00475
(2019/08/20)
Tetracyclic benzimidazole derivatives and combinatorial libraries thereof
The present invention relates to novel tetracyclic benzimidazole derivative compounds of the following formula: wherein R1to R10have the meanings described in here. The invention further relates to combinatorial libraries containing two or more such compounds, as well as methods of preparing tetracyclic benzimidazole derivative compounds.
-
(2008/06/13)
The reduction of specific disulfides with titanium(III) chloride
The reaction between titanium(III) chloride and disulfides was investigated.Aryl and alkyl disulfides did not react while heterocyclic aromatic disulfides with a nitrogen α to the sulfur were reduced to the corresponding thiols.Products were identified and characterized by nuclear magnetic resonance and inrared spectra; and melting point comparisons with authentic compounds.The reductions occurred only in the presence of citrate and were found to require 2 moles of titanium(III) per mole of disulfide.
Akers, Hugh A.,Vang, Meng C.,Updike, Tracie D.
p. 1364 - 1366
(2007/10/02)
More Articles about upstream products of 17624-07-6