74470-40-9Relevant academic research and scientific papers
MUSCARINIC M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS
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, (2018/03/25)
The present invention relates to compounds of formula (I), or their isotopic forms, stereoisomers, tautomers or pharmaceutically acceptable salt (s) thereof as muscarinic M1 receptor positive allosteric modulators (M1 PAMs). The present invention describes the preparation, pharmaceutical composition and the use of compound formula (I).
HETEROCYCLIC FUSED PHENANTHROLINONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS
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Page/Page column 29-30, (2012/01/06)
The present invention is directed to heterocyclic fused phenanthrolinone compounds of formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, schizophrenia, pain or sleep disorders. The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases mediated by the M1 receptor.
S-methylation of N-containing heterocyclic thiols with conjugated acids of methoxy groups
Shimizu, Masao,Shimazaki, Teruaki,Kon, Yoshihiro,Konakahara, Takeo
experimental part, p. 413 - 420 (2010/09/05)
2-Mercaptopyridine-3-carboxylic acid reacts with methanol under acidic conditions to afford the corresponding S-methylated methyl ester, methyl 2-methylthiopyridine-2-carboxylate. Such S-methylation occurred for various N-containing heterocyclic thiols wi
CARBINOL DERIVATIVES HAVING CYCLIC LINKER
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Page/Page column 25, (2010/03/31)
[Object] To provide a novel LXRβ agonist that is useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease. [Solving Means] A carbinol compound represented by the following general formula (I) or salt thereof, or their solvate.
Synthesis of pyridone and pyridine rings by [4+2] hetero-cyclocondensation
Robin, Aélig,Julienne, Karine,Meslin, Jean Claude,Deniaud, David
, p. 9557 - 9559 (2007/10/03)
Substituted pyridones and pyridines have been synthesised efficiently by employing iminium salt as a key precursor. These compounds were prepared using tandem [4+2] cycloaddition/deamination between azabutadiene and dienophiles.
