Formamide Catalysis Facilitates the Transformation of Aldehydes into Geminal Dichlorides
Herein, a novel method for the transformation of aldehydes into geminal dichlorides based on phthaloyl chloride as reagent and N -formylpyrrolidine as Lewis base catalyst is disclosed. Given the mild reaction conditions, the current protocol is distinguished by high levels of functional group compatibility and scalability and is operationally simple. The in situ formation of a Vilsmeier Haack reagent type intermediate is likely to be essential for this organocatalytic nucleophilic substitution reaction.
Huy, Peter Helmut
supporting information
p. 2474 - 2483
(2019/06/08)
FORMATION OF 1-CHLOROBENZOCYCLOBUTENE, ANTHRACENE OR BENZOFURAN BY FLASH VACUUM PYROLYSIS
Pyrolysis of o-substituted benzylidene chlorides is shown to be a useful route to 1-chlorobenzocyclobutene, anthracene or benzofurans; evidence is given for a carbene intermediate in the pyrolysis of o-methoxybenzylidene chloride.
Hussain, Amjad,Parrick, John
p. 609 - 612
(2007/10/02)
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