cas 1770812-37-7, (S)-4,5-dichloro-N-((2-oxo-3-(4-(3-oxoMorpholino)phenyl)oxazolidin-5-yl)Methyl)thiophene-2-carboxaMide | Articles data ｜lookchem

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1770812-37-7

Articles about 1770812-37-7Total 3 be found

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A related substance [...] F, G synthetic method
The invention provides synthetic methods of related substances F and G of rivaroxaban. With the adoption of the synthetic methods of the related substances F and G of the rivaroxaban, the yield is high, and industrial production and technology transformation are realized easily.
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Paragraph 0085-0089; 0092; 0095

(2018/03/01)

A oxazolidinone compounds of preparation method
The invention discloses a method for preparing an oxazolidinone compound. The method comprises the following steps of carrying out ammonolysis reaction on a racemic or optically active 3-chloro-2-hydroxypropyl aniline compound (2) as a starting material and ammonia in a proper solvent and under alkaline condition to obtain a 3-amino-2-hydroxypropyl aniline compound (3); carrying out acylation reaction on the compound (3) to obtain 3-acylamino-2-hydroxypropyl aniline compound (4); and carrying out cyclization reaction on the compound (4) and a corresponding acylating reagent to obtain the racemic or optically active oxazolidinone compound (II) as shown in the description, wherein R1 represents morpholinyl or 3-oxo-4-morpholinyl; R2 represents H or F; and R3 represents C1-12 alkyl, 5-chloro-thiophen-2-yl, thiophen-2-yl or 4,5-dichloro-2-yl; and the compound is a racemate and (S)- or (R)- optical isomers.
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Paragraph 0081; 0082; 0083; 0114; 0115; 0116

(2017/08/25)

An Improved Synthesis of Rivaroxaban
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Tian, Shaixiao,Tang, Bo,Zhang, Minzhong,Gao, Qingjiao,Chen, Bo,Zhang, Qinghua,Xu, Guangyu
p. 169 - 177
(2017/04/26)

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Chemical Properties

Boiling Point: 718.5±60.0 °C(Predicted)
Density: 1.514±0.06 g/cm3(Predicted)
PKA: 12.52±0.46(Predicted)
PSA: 116.42000
LogP: 3.69420

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