1770812-37-7

Basic information

• Product Name: (S)-4,5-dichloro-N-((2-oxo-3-(4-(3-oxoMorpholino)phenyl)oxazolidin-5-yl)Methyl)thiophene-2-carboxaMide
• Synonyms: (S)-4,5-dichloro-N-((2-oxo-3-(4-(3-oxoMorpholino)phenyl)oxazolidin-5-yl)Methyl)thiophene-2-carboxaMide;Rivaroxaban Dichloro Impurity;Rivaroxaban ImpIV
• CAS NO: 1770812-37-7
• Molecular Formula: C19H17Cl2N3O5S
• Molecular Weight: 470.32638
• Mol File: 1770812-37-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 718.5±60.0 °C(Predicted)
• Appearance: /
• Density: 1.514±0.06 g/cm3(Predicted)
• PKA: 12.52±0.46(Predicted)
• CAS DataBase Reference: (S)-4,5-dichloro-N-((2-oxo-3-(4-(3-oxoMorpholino)phenyl)oxazolidin-5-yl)Methyl)thiophene-2-carboxaMide(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-4,5-dichloro-N-((2-oxo-3-(4-(3-oxoMorpholino)phenyl)oxazolidin-5-yl)Methyl)thiophene-2-carboxaMide(1770812-37-7)
• EPA Substance Registry System: (S)-4,5-dichloro-N-((2-oxo-3-(4-(3-oxoMorpholino)phenyl)oxazolidin-5-yl)Methyl)thiophene-2-carboxaMide(1770812-37-7)

Safety Data

• Hazardous Substances Data: 1770812-37-7(Hazardous Substances Data)

Usage

Uses

4,5-Dichloro-N-[[(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-2-thiophenecarboxamide is an impurity of Rivaroxaban (R538000), a novel antithrombotic agent. A highly potent and selective, direct FXa inhibitor.

Upstream product

• 89283-13-6 4,5-dichlorothiophene-2-carbonyl chloride 
• 898543-06-1 4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidine-3-yl]phenyl}morpholin-3-one hydrochloride 
• 1327778-39-1 ethyl N-[4-(3-oxo-4-morpholinyl)phenyl]carbamate 
• 438056-69-0 4-(4-aminophenyl)morpholin-3-one 
• 530-62-1 1,1'-carbonyldiimidazole 
• 1252018-10-2 4-[4-(N-(3-chloro-(2R)-2-hydroxy-1-propyl)amino)phenyl]morpholin-3-one 
• 1403383-56-1 (S)-4-[4-[(3-amino-2-hydroxypropyl)amino]phenyl]-3-morpholinone 
• 31166-29-7 4,5-dichlorothiophene-2-carboxylic acid 
• 79-22-1 methyl chloroformate 

Relevant articles and documents

A related substance [...] F, G synthetic method

The invention provides synthetic methods of related substances F and G of rivaroxaban. With the adoption of the synthetic methods of the related substances F and G of the rivaroxaban, the yield is high, and industrial production and technology transformation are realized easily.

A oxazolidinone compounds of preparation method

The invention discloses a method for preparing an oxazolidinone compound. The method comprises the following steps of carrying out ammonolysis reaction on a racemic or optically active 3-chloro-2-hydroxypropyl aniline compound (2) as a starting material and ammonia in a proper solvent and under alkaline condition to obtain a 3-amino-2-hydroxypropyl aniline compound (3); carrying out acylation reaction on the compound (3) to obtain 3-acylamino-2-hydroxypropyl aniline compound (4); and carrying out cyclization reaction on the compound (4) and a corresponding acylating reagent to obtain the racemic or optically active oxazolidinone compound (II) as shown in the description, wherein R1 represents morpholinyl or 3-oxo-4-morpholinyl; R2 represents H or F; and R3 represents C1-12 alkyl, 5-chloro-thiophen-2-yl, thiophen-2-yl or 4,5-dichloro-2-yl; and the compound is a racemate and (S)- or (R)- optical isomers.