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5'-O-(4,4'-DIMETHOXYTRITYL)-2'-FLUORO-D-CYTIDINE, also known as 2''-Deoxy-5''-O-DMT-2''-fluorocytidine, is a nucleoside building block derived from the modification of cytidine, a nucleobase in the structure of DNA and RNA. It is characterized by the presence of a 2'-fluoro group and a 5'-O-(4,4'-dimethoxytrityl) group, which contribute to its unique properties and applications in various fields.

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  • 177086-37-2 Structure
  • Basic information

    1. Product Name: 5'-O-(4,4'-DIMETHOXYTRITYL)-2'-FLUORO-D-CYTIDINE
    2. Synonyms: 5'-O-(4,4'-DIMETHOXYTRITYL)-2'-FLUORO-D-CYTIDINE;2'-Deoxy-5'-O-DMT-2'-fluorocytidine;5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-cytidine
    3. CAS NO:177086-37-2
    4. Molecular Formula: C30H30FN3O6
    5. Molecular Weight: 547.57
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 177086-37-2.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 5'-O-(4,4'-DIMETHOXYTRITYL)-2'-FLUORO-D-CYTIDINE(CAS DataBase Reference)
    10. NIST Chemistry Reference: 5'-O-(4,4'-DIMETHOXYTRITYL)-2'-FLUORO-D-CYTIDINE(177086-37-2)
    11. EPA Substance Registry System: 5'-O-(4,4'-DIMETHOXYTRITYL)-2'-FLUORO-D-CYTIDINE(177086-37-2)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 177086-37-2(Hazardous Substances Data)

177086-37-2 Usage

Uses

Used in Pharmaceutical Industry:
5'-O-(4,4'-DIMETHOXYTRITYL)-2'-FLUORO-D-CYTIDINE is used as a nucleoside building block for the synthetic preparation of di(2''-?deoxy-?2''-?fluoro)?nucleoside phosphates and phosphorothioates. These synthetic compounds have potential applications in the development of new drugs, particularly in the treatment of viral infections and cancer.
In the field of nucleic acid chemistry, this compound serves as an essential intermediate for the synthesis of modified oligonucleotides, which can be used as therapeutic agents or research tools for studying gene expression and regulation.
Additionally, 5'-O-(4,4'-DIMETHOXYTRITYL)-2'-FLUORO-D-CYTIDINE can be utilized in the development of novel drug delivery systems, such as nanoparticles or liposomes, to improve the bioavailability and targeting of therapeutic agents.

Check Digit Verification of cas no

The CAS Registry Mumber 177086-37-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,7,0,8 and 6 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 177086-37:
(8*1)+(7*7)+(6*7)+(5*0)+(4*8)+(3*6)+(2*3)+(1*7)=162
162 % 10 = 2
So 177086-37-2 is a valid CAS Registry Number.

177086-37-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-[(2R,3R,4R,5S)-4-amino-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-fluorooxolan-2-yl]pyrimidine-2,4-dione

1.2 Other means of identification

Product number -
Other names 2'-Deoxy-5'-O-DMT-2'-fluorocytidine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:177086-37-2 SDS

177086-37-2Downstream Products

177086-37-2Relevant articles and documents

Antisense modulation of CD40 ligand expression

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Page/Page column 18, (2008/06/13)

Antisense compounds, compositions and methods are provided for modulating the expression of CD40 ligand. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding CD40 ligand. Methods of using these compounds for modulation of CD40 ligand expression and for treatment of diseases associated with expression of CD40 ligand are provided.

ANTISENSE MODULATION OF ENDOTHELIAL LIPASE EXPRESSION

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Page 51, (2010/11/30)

Antisense compounds, compositions and methods are provided for modulating the expression of Endothelial Lipase (EL). The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding EL. Methods of using these compounds for modulation of EL expression and for treatment of diseases associated with expression of EL are provided.

Notch1 inhibitors for inducing apoptosis

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Page 18, (2008/06/13)

Compounds, compositions and methods are provided for modulating the expression of Notch1. The compositions comprise oligonucleotides, targeted to nucleic acid encoding Notch1. Methods of using these compounds for modulation of Notch1 expression and for diagnosis and treatment of disease associated with expression Notch1 are provided.

Antisense modulation of PLML expression

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Page 18, (2010/02/03)

Antisense compounds, compositions and methods are provided for modulating the expression of PLML. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PLML. Methods of using these compounds for modulation of PLML expression and for treatment of diseases associated with expression of PLML are provided.

OLIGONUCLEOTIDES HAVING MODIFIED NUCLEOSIDE UNITS

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Page 222, (2010/02/04)

Disclosed are oligonucleotides and oligonucleosides that include one or more modified nucleoside units. The oligonucleotides and oligonucleosides are particularly useful as antisense agents, ribozymes, aptamer, siRNA agents, probes and primers or, when hybridized to an RNA, as a substrate for RNA cleaving enzymes including RNase H and dsRNase.

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