- Microwave-assisted phenothiazines preparation by thionation of diphenylamines
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A preparation in 'dry media' of phenothiazine derivatives by thionation of diphenylamines using microwave-activation is presented. This method allowed the preparation of 2,4,6,8-tetra-tert-butyl-10H-phenothiazine 2e, the first 2,4,6,8-tetra-substituted derivative of this heterocycle, practically inaccessible by other thionation procedure.
- Filip, Sorin V.,Silberg, Ioan A.,Surducan, Emanoil,Vlassa, Mircea,Surducan, Vasile
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Read Online
- A 2-methoxy phenothiazine synthesis method (by machine translation)
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The present invention provides a 2-methoxy phenothiazine synthesis method, comprising the following steps: step a, uniformly mixing the resorcinol and aniline, the heating and stirring add catalyst dehydration occurs under amination reaction produce intermediate I; step two, intermediate I plus solvent and alkali, under the heating conditions for the etherification reaction reagent instillment methylation intermediate II; step three, intermediate II plus solvent and sulfur, heating reflow conditions the initiation reaction of the iodine, the beginning of the generating ring reaction product 2-methoxy phenothiazine; step four, initial product 2-methoxy phenothiazine solvent recrystallization to obtain pure 2-methoxy phenothiazine. This invention adopts the single solvent, is not only conducive to separation and purification of the product, but also effectively reduce the cost of the solvent, also improve the industrial cleaning and safety of preparing reaction, the environmental pollution is reduced. At the same time separation, the recovered solvent can be recycled. (by machine translation)
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Page/Page column 0024; 0027
(2016/10/24)
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- Improved synthesis of 2-methoxyphenothiazine
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A procedure for synthesis of 2-methoxyphenothiazine (1) has been developed, starting from resorcinol and aniline by condensation, following methylation and cyclization. p-Toluenesulfonic acid and polysubstituted aromatics were employed as the catalyst of condensation and the solvent of cyclization, respectively, to improve the yield. The use of parallel experiments, statistical experimental design, and multivariate modeling made the total yield of the procedure as high as 74.2%. Copyright
- Ruan, Jian-Cheng,Zhang, Tao,Wang, Shuai,Liu, Jin-Qiang,Qian, Chao,Chen, Xin-Zhi
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experimental part
p. 438 - 441
(2012/07/03)
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- Assembly of substituted phenothiazines by a sequentially controlled CuI/L-proline-catalyzed cascade C-S and C-N bond formation
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(Chemical equation presented) In the pro-line of fire: A general and efficient cascade reaction approach to substituted phenothiazines, which relies on controlled sequential Cul/L-prolinecatalyzed C-S and C-N bond formations, is described. DMSO = dimethylsulfoxide.
- Dawei, Ma.,Geng, Qian,Zhang, Hui,Jiang, Yongwen
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supporting information; experimental part
p. 1291 - 1294
(2010/05/17)
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