Copper-Catalyzed Tandem Reaction of 2-Aminobenzamides with Tertiary Amines for the Synthesis of Quinazolinone Derivatives
We developed a copper-catalyzed tandem reaction of 2-aminobenzamides with tertiary amines for the formation of quinazolinone derivatives. The strategy includes two steps (cyclization and coupling) performed in one pot. A number of substrates reacted well under standard conditions to give the corresponding quinazolinone derivatives in moderate to good yields.
Deep eutectic solvent mediated synthesis of quinazolinones and dihydroquinazolinones: Synthesis of natural products and drugs
A mild and greener protocol was developed to synthesize substituted quinazolinones and dihydroquinazolinones via deep eutectic solvent (DES) mediated cyclization with a series of aliphatic, aromatic, and heteroaromatic aldehydes in good to excellent yields. This greener strategy was further utilised to synthesize various quinazolinone natural products and drugs.
Ghosh, Suman Kr,Nagarajan, Rajagopal
p. 27378 - 27387
(2016/04/04)
NMR analysis of restricted internal rotation in 2-substituted-2,3-dihydro-3-o-tolyl(chlorophenyl)-4(1H)-quinazolinones
Steric interactions between aryl and heterocyclic moieties in 2-substituted-2,3-dihydro-3-o-tolyl(chlorophenyl)-4(1H)-quinazolinones 1a-j produce sufficient restriction to rotation about the aryl C-N bond that the presence of torsional isomers may be dete
Noto, Renato,Gruttadauria, Michelangelo,Lo Meo, Paolo,Pace, Andrea
p. 1067 - 1071
(2007/10/03)
4-oxo-1,2,3,4-tetrahydroquinazolines. I. Syntheses and pharmacological properties of 2-methyl-3-aryl-4-oxo-1,2,3,4-tetrahydroquinazolines and their 1-acyl derivatives.
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Okumura,Oine,Yamada,Hayashi,Nakama
p. 348 - 352
(2007/10/04)
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