1773-01-9Relevant academic research and scientific papers
Deep eutectic solvent mediated synthesis of quinazolinones and dihydroquinazolinones: Synthesis of natural products and drugs
Ghosh, Suman Kr,Nagarajan, Rajagopal
, p. 27378 - 27387 (2016/04/04)
A mild and greener protocol was developed to synthesize substituted quinazolinones and dihydroquinazolinones via deep eutectic solvent (DES) mediated cyclization with a series of aliphatic, aromatic, and heteroaromatic aldehydes in good to excellent yields. This greener strategy was further utilised to synthesize various quinazolinone natural products and drugs.
Copper-Catalyzed Tandem Reaction of 2-Aminobenzamides with Tertiary Amines for the Synthesis of Quinazolinone Derivatives
Xu, Wei,Zhu, Xiao-Rui,Qian, Peng-Cheng,Zhang, Xing-Guo,Deng, Chen-Liang
supporting information, p. 2851 - 2857 (2016/12/16)
We developed a copper-catalyzed tandem reaction of 2-aminobenzamides with tertiary amines for the formation of quinazolinone derivatives. The strategy includes two steps (cyclization and coupling) performed in one pot. A number of substrates reacted well under standard conditions to give the corresponding quinazolinone derivatives in moderate to good yields.
NMR analysis of restricted internal rotation in 2-substituted-2,3-dihydro-3-o-tolyl(chlorophenyl)-4(1H)-quinazolinones
Noto, Renato,Gruttadauria, Michelangelo,Lo Meo, Paolo,Pace, Andrea
, p. 1067 - 1071 (2007/10/03)
Steric interactions between aryl and heterocyclic moieties in 2-substituted-2,3-dihydro-3-o-tolyl(chlorophenyl)-4(1H)-quinazolinones 1a-j produce sufficient restriction to rotation about the aryl C-N bond that the presence of torsional isomers may be dete
