- Rapid cesium fluoride catalyzed synthesis of 5-aryloxy-1-phenyl-1htetrazoles via nucleophilic aromatic substitution
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A nucleophilic aromatic substitution via a new and facile cesium fluoride catalyzed synthetic approach to get 5-aryloxy-1-phenyl-1H-tetrazoles was developed. Dual usage of cesium fluoride as a nucleophilic catalyst as well as an electrophilic catalyst aff
- Khan, Khalid Mohammed,Fatima, Itrat,Perveen, Shahnaz,Saad, Syed Muhammad
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p. 389 - 394
(2021/09/07)
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- A Mild and Selective Method for the Catalytic Hydrodeoxygenation of Cyanurate Activated Phenols in Multiphasic Continuous Flow
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A low-energy, high-selectivity approach to the catalytic hydrodeoxygenation of phenols is reported using batch or continuous flow methods to react 3 equiv of phenol with cyanuric chloride then hydrogenolyzing the triarylcyanurate intermediate to give 3 equiv of deoxo aromatic. The use of cyanuric chloride compares favorably with existing activation methods, showing improved scalability, atom efficiency, and economics. The scope of both the activation and hydrogenolysis stages are explored using lignin-related phenols. Initial development has identified that continuous stir tank reactors (CSTRs) enable a multiphasic process for converting guaiacol to anisole and at steady state overcome the catalyst deactivation issues observed in batch, seemingly caused by the cyanurate byproduct. Green chemistry aspects and the potential for industrial adoption are discussed.
- Zhao, Yuhan,King, Georgina,Kwan, Maria H.T.,Blacker, A. John
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p. 2012 - 2018
(2017/02/10)
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- Tetrazoles. 33. New method for obtaining functionally substituted tetrazoles
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The interaction of 5-methylsulfonyl-1-phenyltetrazole with C-, N-, and O-nucleophiles at 18-20°C gives high yields of 1-phenyltetrazoles that are functionally substituted on the carbon atom of the heteroring. Prospects are examined for the use of 5-methyl
- Gol'tsberg,Koldobskii
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p. 1300 - 1304
(2007/10/03)
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- METAL-ASSISTED REACTIONS-13. RAPID, SELECTIVE REDUCTIVE CLEAVAGE OF PHENOLIC HYDROXYL GROUPS BY CATALYTIC TRANSFER METHODS
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Previous work has shown that, after converting phenols into suitable phenolic ethers, the aromatic C-O bond of the original phenol can be reductively cleaved heterogeneously to give a C-H bond through the use of molecular hydrogen or hydrogen donors together with a transition metal catalyst.The present work provides a method for selectively replacing a phenolic OH group by H in just a few minutes, compared with the 2 to 4 hr required previously using a hydrogen donor and the several hours under pressure required for molecular hydrogen.Various kinds of groups are suitable for preparing the required phenolic ethers from phenols, but the best ones are strongly electronwithdrawing heteroaromatic entities.Solvent appears to play an important role in this heterogeneous reaction, the mechanism of which is discussed.
- Hussey, Brendan J.,Johnstone, A. W.,Entwistle, Ian D.
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p. 3775 - 3781
(2007/10/02)
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