PIPERIDINE AND HEXAHYDROPYRIDAZINE THROMBIN INHIBITORS
Compounds of the invention have the following structure: STR1
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(2008/06/13)
Synthesis, evaluation, and crystallographic analysis of L-371,912: A potent and selective active-site thrombin inhibitor
Removal of the β-ketoamide functionality from L-370,518 (K(i) = 0.09 nM) provided a 5 nM K(i) inhibitor of thrombin: L-371,912. Comparison of the enzyme-inhibitor crystal structures suggests a possible explanation for the relatively small change in affini
Lyle, Terry A.,Chen, Zhongguo,Appleby, Sandra D.,Freidinger, Roger M.,Gardell, Stephen J.,Lewis, S. Dale,Li, Ying,Lyle, Elizabeth A.,Lynch Jr., Joseph J.,Mulichak, Anne M.,Ng, Assunta S.,Naylor-Olsen, Adel M.,Sanders, William M.
p. 67 - 72
(2007/10/03)
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