Kinetic resolution of diarylmethanols using a mutated variant of lipase CALB
An enzymatic kinetic resolution of diarylmethanols via acylation has been developed. This was achieved by the use of a mutated variant of CALB that accepts larger substrates compared to the wild type. By the use of diarylmethanols with two differently sized aryl groups, enantioselective transformations were achieved. A larger size-difference led to a higher enantioselectivity. In addition, substrates with electronically different aryl groups, such as phenyl and pyridyl, also gave an enantioselective reaction. The highest E value was observed with a substrate where steric and electronic effects were combined.
Synthesis of chiral pyridyl alcohols using a two-step catalytic approach
Chira l pyridyl alcohols have been prepared by developing a two-step approach that uses the asymmetric cyanation of aldehydes to give cyanohydrins and subsequent [2+2+2]-cyclotrimerization reaction with acetylene. Georg Thieme Verlag Stuttgart.
Heller, Barbara,Redkin, Dmitry,Gutnov, Andrey,Fischer, Christine,Bonrath, Werner,Karge, Reinhard,Hapke, Marko
p. 69 - 74
(2008/09/21)
More Articles about upstream products of 177602-10-7