17797-10-3

Basic information

• Product Name: 1-(4-FLUOROPHENYL)-1-METHYL-ETHYLAMINE
• Synonyms: 1-(4-FLUOROPHENYL)-1-METHYL-ETHYLAMINE;1-(4-Fluorophenyl)-1-methylethylamine 97%;1-(4-Fluorophenyl)-1-methylethylamine97%;2-(4-fluorophenyl)propan-2-amine;alpha,alpha-Dimethyl-4-fluorobenzylamine;1-(4-Fluorophenyl)-1-methylethylamine, 2-(4-Fluorophenyl)propan-2-amine;BenzeneMethanaMine, 4-fluoro-a,a-diMethyl-;1-(4-Fluorophenyl)-1-methylethylamine, alpha,alpha-Dimethyl-4-fluorobenzylamine
• CAS NO: 17797-10-3
• Molecular Formula: C₉H₁₂FN
• Molecular Weight: 153.2
• Product Categories: Aminomethyl's;Phenyls & Phenyl-Het;Phenyls & Phenyl-Het
• Mol File: 17797-10-3.mol

Chemical Properties

• Boiling Point: 200.6°C at 760 mmHg
• Flash Point: 84.1°C
• Appearance: Clear colorless/Liquid
• Density: 1.038g/cm³
• Vapor Pressure: 0.321mmHg at 25°C
• Refractive Index: 1.502
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 1-(4-FLUOROPHENYL)-1-METHYL-ETHYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-FLUOROPHENYL)-1-METHYL-ETHYLAMINE(17797-10-3)
• EPA Substance Registry System: 1-(4-FLUOROPHENYL)-1-METHYL-ETHYLAMINE(17797-10-3)

Safety Data

• Hazard Codes: C
• Statements: 34-36/37/38
• Safety Statements: 26-36/37/39
• RIDADR: 3259
• HazardClass: IRRITANT
• Hazardous Substances Data: 17797-10-3(Hazardous Substances Data)

Usage

Uses

1. Used in Pharmaceutical Synthesis:
1-(4-FLUOROPHENYL)-1-METHYL-ETHYLAMINE is used as a synthetic intermediate for the development of potent cannabinoid CB1 receptor agonists. These agonists have potential therapeutic applications in treating various conditions, such as pain, inflammation, and anxiety, by modulating the endocannabinoid system.
2. Used in Pharmaceutical Synthesis (continued):
1-(4-FLUOROPHENYL)-1-METHYL-ETHYLAMINE is also utilized in the synthesis of potent antagonists of NPBWR1 (GPR7). These antagonists may have potential applications in the treatment of various disorders, including cardiovascular diseases, metabolic syndrome, and obesity, by targeting the NPBWR1 receptor.
3. Used in the Chemical Industry:
In addition to its pharmaceutical applications, 1-(4-FLUOROPHENYL)-1-METHYL-ETHYLAMINE may also be used as a building block or intermediate in the chemical industry for the synthesis of other complex organic molecules with diverse applications.

InChI:InChI=1/C9H12FN/c1-9(2,11)7-3-5-8(10)6-4-7/h3-6H,11H2,1-2H3

Upstream product

• 64798-46-5 p-fluoro-α,α-dimethylbenzyl isocyanate 
• 402-41-5 4-fluorocumyl alcohol 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 1194-02-1 4-fluorobenzonitrile 
• 1000141-64-9 C₉H₁₀FN₃ 
• 917-54-4 methyllithium 
• 403-33-8 methyl 4-flurobenzoate 
• 403-39-4 1-fluoro-4-isopropylbenzene 

Downstream Products

• 97872-12-3 2-Benzo[d]isoxazol-3-yl-N-[1-(4-fluoro-phenyl)-1-methyl-ethyl]-acetamide 
• 97872-27-0 2-Benzo[d]isoxazol-3-yl-N-[1-(4-fluoro-phenyl)-1-methyl-ethyl]-butyramide 
• 1000141-67-2 C₁₈H₂₂F₂N₂O₂S 
• 1327826-18-5 N-(1-methyl-1-(4-fluorophenyl)ethyl)picolinamide 
• 1422208-54-5 C₁₉H₂₅FN₂O*ClH 
• 1422207-60-0 C₃₃H₄₂FN₃O₃ 
• 1422208-39-6 C₂₄H₃₃FN₂O₃ 
• 1418283-32-5 N-[2-(4-fluorophenyl)propan-2-yl]-2-(2,4-dichlorophenoxy)propanamide 
• 1357456-31-5 C₂₉H₃₄ClFN₄OS 

Relevant articles and documents

Optimization of N-benzyl-5-nitrofuran-2-carboxamide as an antitubercular agent

The optimization campaign for a nitrofuran antitubercular hit (N-benzyl-5-nitrofuran-2-carboxamide; JSF-3449) led to the design, synthesis, and biological profiling of a family of analogs. These compounds exhibited potent in vitro antitubercular activity (MIC = 0.019–0.20 μM) against the Mycobacterium tuberculosis H37Rv strain and low in vitro cytotoxicity (CC50 = 40–>120 μM) towards Vero cells. Significant improvements in mouse liver microsomal stability and mouse pharmacokinetic profile were realized by introduction of an α α-dimethylbenzyl moiety. Among these compounds, JSF-4088 is highlighted due to its in vitro antitubercular potency (MIC = 0.019 μM) and Vero cell cytotoxicity (CC50 > 120 μM). The findings suggest a rationale for the continued evolution of this promising series of antitubercular small molecules.

NITROGEN-CONTAINING SATURATED HETEROCYCLIC COMPOUND

The present invention provides a compound represented by the following formula (I) or its pharmaceutically acceptable salt: [wherein, R1 represents optionally substituted C1-4 alkyl, n shows integer of 1 to 4, R2 represents optionally substituted C1-4 alkyl or hydrogen atom, R3 represents optionally substituted C1-4 alkyl, R4a, R4b, R4c, and R4d, similarly or differently, represent optionally substituted C6-14 aryl, optionally substituted C1-4 alkyl, or hydrogen atom and the like, A represents optionally substituted C6-14 aryl or optionally substituted 5 to 11 membered heteroaryl].

CANNABINOID RECEPTOR LIGANDS AND USES THEREOF

Compounds of Formula (I) that act as cannabinoid receptor ligands and their uses in the treatment of diseases linked to the mediation of the cannabinoid receptors in animals are described herein.

Evidence for significant through-space and through-bond electronic coupling in the 1,4-diphenylcyclohexane-1,4-diyl radical cation gained by absorption spectroscopy and DFT calculations

Photoinduced single-electron-transfer promoted oxidation of 2,5-diphenyl-l,5-hexadiene by using N-methylquinolinium tetrafluoroborate/ biphenyl co-sensitization takes place with the formation of an intense electronic absorption band at 476 nm, which is attributed to the 1,4-diphenylcyclohexane-1,4-diyl radical cation. The absorption maximum (λob) of this transient occurs at a longer wavelength than is expected for either the cumyl radical or the cumyl cation components. Substitution at the para positions of the phenyl groups in this radical cation by CH3O, CH3, F, Cl, and Br leads to an increasingly larger redshift of λob. A comparison of the ρ value, which was obtained from a Hammett plot of the electronic transition energies of the radical cations versus σ+, with that for the cumyl cation shows that the substituent effects on the transition energies for the 1,4-diarylcyclohexane-1,4-diyl radical cations are approximately one half of the substituent effects on the transition energies of the cumyl cation. The observed substitu_ent-induced redshifts of λob and the reduced sensitivity of λob to substituent changes are in accordance with the proposal that significant through-space and -bond electronic interactions exist between the cumyl radical and the cumyl cation moieties of the 1,4-diphenylcyclohexane-1,4-diyl radical cation. This proposal gains strong support from the results of density functional theory (DFT) calculations. Moreover, the results of time-dependent DFT calculations indicate that the absorption band at 476 nm for the 1,4-diphenylcyclohexane-1,4-diyl radical cation corresponds to a SOMO-3-SOMO transition.

Heterosubstituted pyridine derivatives as PDE4 inhibitors

The invention encompasses the novel compound of Formula I useful in the treatment of diseases, including asthma, by raising the level of cyclic adenosine-3′,5′-monophosphate (cAMP) through the inhibition of phosphodiesterase IV (PDE 4). or a pharmaceutically acceptable salt or hydrate thereof. The invention also encompasses pharmaceutical compositions and methods for treatment.

Steroid derivatives for the treatment of prostatic hypertrophy their preparation and uses

The invention includes compounds of formula (I): STR1 in which R1 is hydrogen, alkyl, aryl-substituted alkyl or aromatic heterocyclic-substituted alkyl; R2 is aryl-substituted alkyl, aromatic heterocyclic-substituted alkyl or diarylamino; and R3 is carboxy or a group of formula --CONHSO2 R4 wherein R4 is alkyl; and pharmaceutically acceptable salts and esters of the compounds. The compounds have valuable 5α-reductase inhibitory activity and can thus be used for the treatment and prophylaxis of, inter alia, prostatic hypertrophy as well as other disorders arising from excess levels of 5α-dihydro-testosterone.

Synthesis and Herbicidal Activities of 1,2-Benzisoxazole-3-acetamide Derivatives

Many 1,2-benzisoxazole-3-acetamides were synthesized and their herbicidal activities in the paddy field were studied.Of the compounds tested, N-α,α-dimethylbenzyl-2-bromo-(1,2-benzisoxazol-3-yl)acetamide 10a was the most effective.Details of the synthesis and the results of herbicidal evaluations are given.