- Reactions of benzonitrile oxide with methoxypyrimidines and pyrimidones
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Methoxypyrimidines preferentially add to benzonitrile oxide to give cycloadducts to their C=N double bonds. These, however, lose benzonitrile affording the corresponding pyrimidones. Cycloadditions to their C=C double bonds take place to a very low extent, and products generally undergo a ring opening process which affords the corresponding oximes. Pyrimidones preferentially give addition products to their nitrogen atoms, and only in the case of 4-pyrimidone, the cycloadduct to its C=C double bond was isolated.
- Corsaro, Antonino,Pistara, Venerando,Rescifina, Antonio,Chiacchio, Maria A.,Piperno, Anna,Romeo, Giovanni
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p. 1079 - 1097
(2007/10/03)
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- Cycloaddition of benzonitrile oxide to pyridazine, pyrimidine and pyrazine
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Cycloaddition of benzonitrile oxide to pyridazine affords an isolable mono-cycloadduct. In cycloadditions to pyrimidine and pyrazine the primary mono-cycloadducts are labile intermediates which undergo further cycloaddition affording isolable bis- and tris-cycloadducts.
- Corsaro, Antonino,Perrini, Giancarlo,Pistara, Venerando,Quadrelli, Paolo,Gamba Invernizzi, Anna,Caramella, Pierluigi
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p. 6421 - 6436
(2007/10/03)
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