178047-66-0Relevant academic research and scientific papers
Reactions of benzonitrile oxide with methoxypyrimidines and pyrimidones
Corsaro, Antonino,Pistara, Venerando,Rescifina, Antonio,Chiacchio, Maria A.,Piperno, Anna,Romeo, Giovanni
, p. 1079 - 1097 (2007/10/03)
Methoxypyrimidines preferentially add to benzonitrile oxide to give cycloadducts to their C=N double bonds. These, however, lose benzonitrile affording the corresponding pyrimidones. Cycloadditions to their C=C double bonds take place to a very low extent, and products generally undergo a ring opening process which affords the corresponding oximes. Pyrimidones preferentially give addition products to their nitrogen atoms, and only in the case of 4-pyrimidone, the cycloadduct to its C=C double bond was isolated.
Cycloaddition of benzonitrile oxide to pyridazine, pyrimidine and pyrazine
Corsaro, Antonino,Perrini, Giancarlo,Pistara, Venerando,Quadrelli, Paolo,Gamba Invernizzi, Anna,Caramella, Pierluigi
, p. 6421 - 6436 (2007/10/03)
Cycloaddition of benzonitrile oxide to pyridazine affords an isolable mono-cycloadduct. In cycloadditions to pyrimidine and pyrazine the primary mono-cycloadducts are labile intermediates which undergo further cycloaddition affording isolable bis- and tris-cycloadducts.
