N-(Arylsulfonyl)trihaloacetimidoyl Chlorides and Their Reactions with Phosphites
We have developed a convenient synthetic approach to highly reactive N-(arylsulfonyl)trichloro- and -trifluoroacetimidoyl chlorides 2 by reacting the corresponding N-acylsulfonamides with PCl5. The interaction of the imidoyl chlorides with phos
Rassukana, Yuliya V.,Onys'Ko, Petro P.,Grechukha, Anatolii G.,Sinitsa, Anatolii D.
Development of an acyl sulfonamide anti-proliferative agent, ly573636 ? na
The synthesis of 5-bromo-thiophene-2-sulfonic acid 2,4-dichlo- robenzoylamide sodium salt on multikilogram scale is described. The initial clinical supplies were made using carbonyl diimidazole to converge the two fragments. A more efficient acid chloride process has been developed, which also provides better control of impurities and color throughout the synthesis.
Yates, Matthew H.,Kallman, Neil J.,Ley, Christopher P.,Wei, Jeffrey N.
experimental part
p. 255 - 262
(2010/04/22)
Oxidation of N(1-hydroxypolychloroethyl)sulfonamides
N-(2,2,2-Trichloro-1-hydroxyethyl)- and N-(2,2-dichloro-1-hydroxy-2-phenylethyl)arenesulfonamides are oxidized with chromium(VI) oxide to give, respectively, N-(arylsulfonyl)trichloroacetamides and N-(arylsulfbnyl)dichloro(phenyl)acetamidcs. Under analogo
Rozentsveig,Rozentsveig,Levkovskaya,Mirskova
p. 1284 - 1286
(2007/10/03)
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